565770 Sigma-Aldrichγ-Secretase Inhibitor IX - CAS 208255-80-5 - Calbiochem
Gamma-Secretase Inhibitor IX - CAS 208255-80-5, is a cell-permeable inhibitor of γ-secretase (Aβtotal IC₅₀ = 115 nM, Aβ42 IC₅₀ = 200 nM).
More>> Gamma-Secretase Inhibitor IX - CAS 208255-80-5, is a cell-permeable inhibitor of γ-secretase (Aβtotal IC₅₀ = 115 nM, Aβ42 IC₅₀ = 200 nM). Less<<SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Synonyme: DAPT, N-[N-(3,5-Difluorophenacetyl-L-alanyl)]-S-phenylglycine t-Butyl Ester
Empfohlene Produkte
Übersicht
| Replacement Information |
|---|
Key Spec Table
| CAS # | Empirical Formula |
|---|---|
| 208255-80-5 | C₂₃H₂₆F₂N₂O₄ |
Preis & Verfügbarkeit
| Bestellnummer | Verfügbarkeit | Verpackung | St./Pkg. | Preis | Menge | |
|---|---|---|---|---|---|---|
| 565770-10MG |
|
Kst.-Ampulle | 10 mg |
|
— | |
| 565770-5MG |
|
Glasflasche | 5 mg |
|
— |
| Description | |
|---|---|
| Overview | A cell-permeable dipeptide that suppresses Aβ production by blocking γ-secretase (Aβtotal IC50 = 115 nM, Aβ42 IC50 = 200 nM). Prevents Aβ34 generation in murine N2a cells and hAPP/hBACE-1 transfected human HEK 293 cells. Reported to be functionally active in both HEK 293 cells and neuronal cultures without affecting the secretion of amyloid-β precursor protein (APP). Also shown to lower Aβ levels acutely in APP-transgenic mice. Reported to reduce extracellular Aβ plaques and intracellular Aβ accumulation in 3xTgAD transgenic mice. A 25 mM (5 mg/462 µl) solution of γ-Secretase Inhibitor IX (Cat. No. 565784) in DMSO is also available. |
| Catalogue Number | 565770 |
| Brand Family | Calbiochem® |
| Synonyms | DAPT, N-[N-(3,5-Difluorophenacetyl-L-alanyl)]-S-phenylglycine t-Butyl Ester |
| Product Information | |
|---|---|
| CAS number | 208255-80-5 |
| ATP Competitive | N |
| Form | Lyophilized |
| Hill Formula | C₂₃H₂₆F₂N₂O₄ |
| Chemical formula | C₂₃H₂₆F₂N₂O₄ |
| Reversible | N |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
|---|
| Biological Information | |
|---|---|
| Primary Target | Aβtotal |
| Primary Target IC<sub>50</sub> | 115 nM suppressing Aβtotal production; 200 nM suppressing Aβ42 production |
| Purity | ≥98% by HPLC |
| Physicochemical Information | |
|---|---|
| Cell permeable | Y |
| Dimensions |
|---|
| Materials Information |
|---|
| Toxicological Information |
|---|
| Safety Information according to GHS |
|---|
| Safety Information |
|---|
| Product Usage Statements |
|---|
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Transport Information |
|---|
| Supplemental Information |
|---|
| Specifications |
|---|
| Global Trade Item Number | |
|---|---|
| Bestellnummer | GTIN |
| 565770-10MG | 04055977267778 |
| 565770-5MG | 07790788059941 |
Documentation
γ-Secretase Inhibitor IX - CAS 208255-80-5 - Calbiochem SDB
| Titel |
|---|
γ-Secretase Inhibitor IX - CAS 208255-80-5 - Calbiochem Analysenzertifikate
| Titel | Chargennummer |
|---|---|
| 565770 |
Literatur
| Übersicht |
|---|
| Morohashi, Y., et al. 2006. J. Bio. Chem. Vol. 281, 14670. Nishitomo, K. et al. 2006 J. Neurochem. 99, 1555. Oddo, S., et al. 2004. Neuron 43, 321. Dovey, H.F., et al. 2001. J. Neurochem. 76, 173. Sastre, M., et al. 2001. EMBO Rep. 2, 835. Vandermeeren, M., et al. 2001. Neurosci. Lett. 315, 145. |
Datenblatt
| Titel |
|---|
| Reprogramming Cell Fate and Function Novel Strategies for iPSC Generation, Characterization, and Differentiation |
Literaturstellen
| Titel | |
|---|---|
|
|
| Datenblatt | ||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
|