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196878 (±)-Bay K 8644 - CAS 93468-89-4 - Calbiochem

Synthetic dihydropyridine derivative that acts as an active Ca2+ slow channel agonist in neuroendocrine, muscle, thyroid and other cell types.

(±)-Bay K 8644 - CAS 93468-89-4 - Calbiochem: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.

Synonyme: 1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2ʹ-(trifluoromethyl)phenyl]-3-pyridinecarboxylic Acid Methyl Ester

Primary Target: L-type Ca2+ channel
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196878
Preis & Verfügbarkeit

Übersicht

Replacement Information

Key Spec Table

CAS #Empirical Formula
93468-89-4C₁₆H₁₅F₃N₂O₄

Preis & Verfügbarkeit

Bestellnummer VerfügbarkeitVerpackung St./Pkg. Preis Menge
196878-1MG
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      		 Kst.-Ampulle 1 mg
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      196878-5MG
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      Eingeschränkte Verfügbarkeit Eingeschränkte Verfügbarkeit
      Lieferbar 
      Produkt wurde eingestellt
      Begrenzter Lagerbestand
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          Kontakt zum Kundenservice
          Contact Customer Service

          		 Kst.-Ampulle 5 mg
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          Description
          OverviewSynthetic dihydropyridine derivative that acts as an active Ca2+ slow channel agonist in neuroendocrine, muscle, thyroid and other cell types. Prolongs single channel open time without affecting the close time. An L-type Ca2+ channel agonist. Composed of two optical isomers. The (-)-enantiomer has strong vasoconstrictive, positive inotropic, and Ca2+ agonistic properties, whereas the (+)-enantiomer has weakly vasodilating, negative inotropic, and Ca2+ antagonistic properties. The net effect of the racemic mix is that of the negative enantiomer. Promotes β-cell proliferation/regeneration.
          Catalogue Number196878
          Brand Family Calbiochem®
          Synonyms1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2ʹ-(trifluoromethyl)phenyl]-3-pyridinecarboxylic Acid Methyl Ester
          References
          ReferencesWang, W., et al. 2009. Proc. Natl. Acad. Sci. USA 106, 1427.
          Weigl, L.G., et al. 2000. J. Physiol. 525 (pt. 2), 461.
          Vannier, C., et al. 1995. Am. J. Physiol. 268, L201.
          Bechem, M., and Hoffmann, H. 1993. Pflugers Arch. 424, 343.
          Triggle, D.J., and Rompe, D. 1989. Trends Pharmacol. Sci. 10, 507.
          Takasu, N., et al. 1987. Biochem. Biophys. Res. Commun. 143, 1107.
          Tagliatela, M., et al. 1986. Brain Res. 381, 356.
          Franckowiak, G., et al. 1985. Eur. J. Pharmacol. 114, 223.
          Product Information
          CAS number93468-89-4
          ATP CompetitiveN
          FormYellow solid
          Hill FormulaC₁₆H₁₅F₃N₂O₄
          Chemical formulaC₁₆H₁₅F₃N₂O₄
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary TargetL-type Ca2+ channel
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 36/38

          Irritating to eyes and skin.
          S PhraseS: 26-36

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Irritant
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 20 days at 4°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          Bestellnummer GTIN
          196878-1MG 04055977206609
          196878-5MG 04055977206616

          Documentation

          (±)-Bay K 8644 - CAS 93468-89-4 - Calbiochem SDB

          Titel

          Sicherheitsdatenblatt (SDB) 

          (±)-Bay K 8644 - CAS 93468-89-4 - Calbiochem Analysenzertifikate

          TitelChargennummer
          196878

          Literatur

          Übersicht
          Wang, W., et al. 2009. Proc. Natl. Acad. Sci. USA 106, 1427.
          Weigl, L.G., et al. 2000. J. Physiol. 525 (pt. 2), 461.
          Vannier, C., et al. 1995. Am. J. Physiol. 268, L201.
          Bechem, M., and Hoffmann, H. 1993. Pflugers Arch. 424, 343.
          Triggle, D.J., and Rompe, D. 1989. Trends Pharmacol. Sci. 10, 507.
          Takasu, N., et al. 1987. Biochem. Biophys. Res. Commun. 143, 1107.
          Tagliatela, M., et al. 1986. Brain Res. 381, 356.
          Franckowiak, G., et al. 1985. Eur. J. Pharmacol. 114, 223.
          Datenblatt

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision02-February-2009 JSW
          Synonyms1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2ʹ-(trifluoromethyl)phenyl]-3-pyridinecarboxylic Acid Methyl Ester
          DescriptionA synthetic dihydropyridine derivative that is an active Ca2+ slow channel agonist in neuroendocrine, muscle, thyroid, and other cell types. Prolongs single channel open time without affecting the close time. An L-type Ca2+ channel agonist. Composed of two optical isomers. The (-)-enantiomer has strong vasoconstrictive, positive ionotropic, and Ca2+ agonistic properties, whereas the (+)-enantiomer has weak vasodilating, negative ionotropic, and Ca2+ antagonistic properties. The net effect of the racemic mix is that of the negative enantiomer. Promotes β-cell proliferation/regeneration.
          FormYellow solid
          CAS number93468-89-4
          Chemical formulaC₁₆H₁₅F₃N₂O₄
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityEthanol (35 mg/ml) or DMSO (35 mg/ml)
          Storage Protect from light
          +2°C to +8°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 20 days at 4°C.
          Toxicity Irritant
          ReferencesWang, W., et al. 2009. Proc. Natl. Acad. Sci. USA 106, 1427.
          Weigl, L.G., et al. 2000. J. Physiol. 525 (pt. 2), 461.
          Vannier, C., et al. 1995. Am. J. Physiol. 268, L201.
          Bechem, M., and Hoffmann, H. 1993. Pflugers Arch. 424, 343.
          Triggle, D.J., and Rompe, D. 1989. Trends Pharmacol. Sci. 10, 507.
          Takasu, N., et al. 1987. Biochem. Biophys. Res. Commun. 143, 1107.
          Tagliatela, M., et al. 1986. Brain Res. 381, 356.
          Franckowiak, G., et al. 1985. Eur. J. Pharmacol. 114, 223.