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3779 Histamine, Free Base - CAS 51-45-6 - Calbiochem

Descripción

Tabla espec. clave

CAS #Empirical Formula
51-45-6C₅H₉N₃

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3779-1GM
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      Description
      OverviewA potent vasodilator found in normal tissues and blood. Activates nitric oxide synthase. Formed by the decarboxylation of L-histidine. Activation of histamine H1 receptors leads to Ca2+ mobilization, whereas histamine H2 receptor activation stimulates adenylate cyclase activity in neurons. Stimulated time- and concentration-dependent increase in p38 and p42/p44 MAP kinases in DDT(1) MF2 cells.
      Catalogue Number3779
      Brand Family Calbiochem®
      Synonyms2-(4-Imidazolyl)ethylamine
      References
      ReferencesRobinson, A.J., and Dickerson, J.M. 2001. Br. J. Pharmacol. 133, 178.
      Izumi, H., et al. 1995. Am. J. Obstet. Gynecol. 172, 1477.
      Vannier, E., and Dinarello, C.A. 1994. J. Biol. Chem. 269, 9952.
      Yan, Q.Z., et al. 1994. Agents Actions 41, C111.
      Moncada, S., et al. 1991. Pharmacol. Rev. 43, 109.
      Bloom, F.E. 1990. in Pharmacological Basis of Therapeutics p. 224 (Gilman, A.G., et al., Eds.) Pergamon Press, New York.
      Product Information
      CAS number51-45-6
      FormWhite solid
      Hill FormulaC₅H₉N₃
      Chemical formulaC₅H₉N₃
      Hygroscopic Hygroscopic
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Purity≥97% by TLC
      Safety Information according to GHS
      RTECSMS1050000
      Safety Information
      R PhraseR: 22-36/37/38-42/43

      Harmful if swallowed.
      Irritating to eyes, respiratory system and skin.
      May cause sensitization by inhalation and skin contact.
      S PhraseS: 26-36/37-22

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing and gloves.
      Do not breathe dust.
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Número de referencia GTIN
      3779-1GM 07790788049744