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Fmoc-azido Acids


For the incorporation of differentially-protected amino groups within a peptide sequence, we offer derivatives bearing protecting groups cleavable with reagents ranging from mild acids, Pd(0), alpha-effect nucleophiles, and phosphines. Fmoc-azido acids are tools for Fmoc SPPS in which the side-chain amino group is unmasked by reduction. These derivatives can be coupled using standard activation methods. The azido group is stable to both TFA and piperidine, so they can be used in both solid phase and solution phase synthetic strategies. Thiols should be omitted from the TFA cleavage mixture as their use can lead to reduction of the azido group. Liberation of the amine group from the azide has been accomplished by reduction with phosphines, thiols, or Zn/AcOH.

Protocols on use

ProductCatalog number
(2S,3S)-Fmoc-Abu(3-N3)-OH
852352
Fmoc-L-γ-azidohomoalanine-OH 852321
Fmoc-L-azidolysine 852326
Fmoc-L-δ-azidonorvaline-OH 852322
cis-Fmoc.Pro(4.N3).OH 852351