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557440 Ru360 - Calbiochem

Ru360, is a cell-permeable oxygen-bridged dinuclear ruthenium amine complex. Binds to mitochondria with high affinity (Kd = 340 pM) and blocks Ca2+ uptake into mitochondria in vitro (IC₅₀ = 184 pM).

Ru360 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (μ)[(HCO₂)(NH₃)₄Ru]₂OCl₃

Primary Target: Ca2+ uptake into mitochondria in vitro
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557440
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₂H₂₆Cl₃N₈O₅Ru₂

Pricing & Availability

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      Description
      OverviewA cell-permeable oxygen-bridged dinuclear ruthenium amine complex that has been shown to bind to mitochondria with high affinity (Kd = 340 pM). Specifically blocks Ca2+ uptake into mitochondria in vitro (IC50 = 184 pM) and in situ in intact myocytes (complete block after incubation with ~10 µM of Ru360 for 30 min). Does not affect other cellular Ca2+ transport processes involved in cardiac muscle contraction, even at micromolar levels.
      Note: 1 set = 10 x 100 µg.
      Catalogue Number557440
      Brand Family Calbiochem®
      Synonyms(μ)[(HCO₂)(NH₃)₄Ru]₂OCl₃
      References
      ReferencesSanchez, J.A., et al. 2001. J. Physiol. 536, 387.
      Bassani, R.A., et al. 1998. Cell Calcium 23, 433.
      Matlib, M.A., et al. 1998. J. Biol. Chem. 273, 10223.
      Zhou, Z., et al. 1998. J. Physiol. 507 (pt 2), 379.
      Emerson, J., et al. 1993. J. Am. Chem. Soc. 115, 11799.
      Ying, W.-L., et al. 1991. Biochemistry 30, 4949.
      Product Information
      ATP CompetitiveN
      FormGreen solid
      Hill FormulaC₂H₂₆Cl₃N₈O₅Ru₂
      Chemical formulaC₂H₂₆Cl₃N₈O₅Ru₂
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCa2+ uptake into mitochondria in vitro
      Primary Target IC<sub>50</sub>184 pM blocking Ca2+ uptake into mitochondria in vitro; and in situ in intact myocytes; Kd = 340 pM for binding mitochondria
      Purity≥97%
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsUnstable in solution; reconstitute just prior to use.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      557440-1SET 07790788051501

      Documentation

      Ru360 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Ru360 - Calbiochem Certificates of Analysis

      TitleLot Number
      557440

      References

      Reference overview
      Sanchez, J.A., et al. 2001. J. Physiol. 536, 387.
      Bassani, R.A., et al. 1998. Cell Calcium 23, 433.
      Matlib, M.A., et al. 1998. J. Biol. Chem. 273, 10223.
      Zhou, Z., et al. 1998. J. Physiol. 507 (pt 2), 379.
      Emerson, J., et al. 1993. J. Am. Chem. Soc. 115, 11799.
      Ying, W.-L., et al. 1991. Biochemistry 30, 4949.

      Brochure

      Title
      Caspases and other Apoptosis Related Tools Brochure
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision04-August-2021 JSW
      Synonyms(μ)[(HCO₂)(NH₃)₄Ru]₂OCl₃
      DescriptionA cell-permeable oxygen bridged dinuclear ruthenium amine complex that has been shown to bind to mitochondria with high affinity (Kd = 0.34 nM) and specifically blocks Ca2+ uptake into mitochondria in vitro (IC50 = 184 pM) and in situ in intact myocytes (for complete block after incubation with ~10 µM of Ru360 for 30 min. Does not affect other cellular Ca2+ transport processes involved in cardiac muscle contraction even at micromolar levels.
      FormGreen solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂H₂₆Cl₃N₈O₅Ru₂
      Structure formulaStructure formula
      Purity≥97%
      SolubilityDeoxygenated H₂O (0.5 mg/ml)
      Storage Protect from light
      -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsUnstable in solution; reconstitute just prior to use.
      Toxicity Standard Handling
      ReferencesSanchez, J.A., et al. 2001. J. Physiol. 536, 387.
      Bassani, R.A., et al. 1998. Cell Calcium 23, 433.
      Matlib, M.A., et al. 1998. J. Biol. Chem. 273, 10223.
      Zhou, Z., et al. 1998. J. Physiol. 507 (pt 2), 379.
      Emerson, J., et al. 1993. J. Am. Chem. Soc. 115, 11799.
      Ying, W.-L., et al. 1991. Biochemistry 30, 4949.