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553502 Rac1 Inhibitor - CAS 1177865-17-6 - Calbiochem

Rac1 Inhibitor, CAS 1177865-17-6, is a cell-permeable, reversible inhibitor of Rac1 GDP/GTP exchange. Interferes with the interaction between Rac1 and Rac-specific GEFs Trio and Tiam1 (IC₅₀ ~50 µM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: NSC23766

Primary Target: Rac1
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
1177865-17-6C₂₄H₃₈Cl₃N₇

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      Description
      OverviewA cell-permeable pyrimidine compound that specifically and reversibly inhibits Rac1 GDP/GTP exchange activity by interfering with the interaction between Rac1 and Rac-specific GEFs (guanine nucleotide exchange factors) Trio and Tiam1 (IC50 ~50 µM). Shown to effectively inhibit Rac1-mediated cellular functions in NIH3T3 and PC-3 cells (effective dose ~50 to 100 μM). Exhibits no effect on Cdc42 or RhoA activation and does not affect Rac1 interaction with BcrGAP or PAK1. Reduces TRAP-induced and collagen stimulated platelet aggregation (IC50 = 50 mM and 64 mM, respectively).
      Catalogue Number553502
      Brand Family Calbiochem®
      SynonymsNSC23766
      References
      ReferencesDwivedi, S., et al. 2010. J. Translational Med. 8, 128.
      Desire, L., et al. 2005. J. Biol. Chem. 280, 37516.
      Gao, Y., et al. 2004. Proc. Natl. Acad. Sci. USA 101, 7618.
      Product Information
      CAS number1177865-17-6
      ATP CompetitiveN
      FormLyophilized
      Hill FormulaC₂₄H₃₈Cl₃N₇
      Chemical formulaC₂₄H₃₈Cl₃N₇
      Hygroscopic Hygroscopic
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetRac1
      Primary Target IC<sub>50</sub>~50 µM against Rac1 GDP/GTP exchange activity; 50 mM and 64 mM against TRAP-induced and collagen stimulated platelet aggregation
      Purity≥93% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Carcinogenic / Teratogenic
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      553502-5MG 07790788051433

      Documentation

      Rac1 Inhibitor - CAS 1177865-17-6 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Rac1 Inhibitor - CAS 1177865-17-6 - Calbiochem Certificates of Analysis

      TitleLot Number
      553502

      References

      Reference overview
      Dwivedi, S., et al. 2010. J. Translational Med. 8, 128.
      Desire, L., et al. 2005. J. Biol. Chem. 280, 37516.
      Gao, Y., et al. 2004. Proc. Natl. Acad. Sci. USA 101, 7618.

      Citations

      Title
    • Dwivedi, S., et al. 2010. J. Translational Med. 8, 128.
      		•
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision28-February-2012 RFH
      SynonymsNSC23766
      DescriptionA cell-permeable pyrimidine compound that specifically and reversibly inhibits Rac1 GDP/GTP exchange activity by interfering with the interaction between Rac1 and Rac-specific GEFs (guanine nucleotide exchange factors) Trio and Tiam1 (IC50 ~50 µM). Shown to effectively inhibit Rac1-mediated cellular functions in NIH3T3 and PC-3 cells (effective dose ~50 to 100 μM). Exhibits no effect on Cdc42 or RhoA activation and does not affect Rac1 interaction with BcrGAP or PAK1. Reduces TRAP-induced and collagen stimulated platelet aggregation (IC50 = 50 mM and 64 mM, respectively).
      FormLyophilized
      Intert gas (Yes/No) Packaged under inert gas
      CAS number1177865-17-6
      Chemical formulaC₂₄H₃₈Cl₃N₇
      Structure formulaStructure formula
      Purity≥93% by HPLC
      SolubilityH₂O (5 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Carcinogenic / Teratogenic
      ReferencesDwivedi, S., et al. 2010. J. Translational Med. 8, 128.
      Desire, L., et al. 2005. J. Biol. Chem. 280, 37516.
      Gao, Y., et al. 2004. Proc. Natl. Acad. Sci. USA 101, 7618.
      Citation
    • Dwivedi, S., et al. 2010. J. Translational Med. 8, 128.
      		•