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851009 PyBOP

PyBOP Novabiochem®. CAS 128625-52-5, molar mass 520.39 g/mol.

PyBOP MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
CAS #: 128625-52-5 Molar Mass: 520.39 g/mol Hill Formula: C₁₈H₂₈N₆OP * F₆P
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851009
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Overview

Replacement Information

Key Spec Table

CAS #Hill FormulaMolar Mass
128625-52-5C₁₈H₂₈N₆OP * F₆P520.39 g/mol

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      Description
      Catalogue Number851009
      Replaces01-62-0016
      Brand Family Novabiochem®
      Alternate Names
      • Benzotriazole-1-yl-oxy-tris-pyrrolidino-phosphonium hexafluorophosphate
      Background InformationThe standard in situ coupling reagent for solid phase peptide synthesis [1-5]. This product can replace BOP in all applications without loss of performance. Unlike uronium-based reagents, PyBOP® does not give rise to guanidinated by-products during cyclization and fragment condensation reactions.

      The product number for this product was previously 01-62-0016.

      To obtain a certificate of analysis (CoA) of a lot that begins with the letter "A", please select the option in the right hand menu "Request a COA for Lot#s starting with A".
      References
      Product Information
      CAS number128625-52-5
      Hill FormulaC₁₈H₂₈N₆OP * F₆P
      Molar Mass520.39 g/mol
      HS Code2933 99 80
      Structure formula ImageStructure formula Image
      Quality LevelMQ400
      Applications
      ApplicationPyBOP Novabiochem®. CAS 128625-52-5, molar mass 520.39 g/mol.
      Biological Information
      Physicochemical Information
      Density1.438 g/cm3 (20 °C)
      Melting Point140 - 155 °C
      Vapor pressure<1 hPa (25 °C)
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Hazard Pictogram(s) Hazard Pictogram(s)
      Hazard Pictogram(s)
      Hazard Statement(s)H302: Harmful if swallowed.
      H317: May cause an allergic skin reaction.
      H410: Very toxic to aquatic life with long lasting effects.
      Precautionary Statement(s)P261: Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
      P264: Wash skin thoroughly after handling.
      P273: Avoid release to the environment.
      P280: Wear protective gloves.
      P301 + P312: IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell.
      P302 + P352: IF ON SKIN: Wash with plenty of water.
      Signal WordWarning
      Storage class10 - 13 Other liquids and solids
      WGKWGK 3 highly hazardous to water
      Safety Information
      Categories of dangerirritant
      Product Usage Statements
      Storage and Shipping Information
      StorageStore at +2°C to +8°C.
      Packaging Information
      Transport Information
      Declaration (railroad and road) ADR, RIDUN 3077 , 9, III
      Declaration (transport by air) IATA-DGRUN 3077 , 9, III
      Declaration (transport by sea) IMDG-CodeUN 3077 , 9, III, Marine Pollutant: P
      Supplemental Information
      Specifications
      Color (visual)white to slight yellow to beige
      Appearance of substance (visual)powder
      Identity (IR)passes test
      Assay (HPLC, area%)≥ 99.0 % (a/a)
      Solubility (1 mmole in 2 ml DMF)clearly soluble
      Global Trade Item Number
      Catalogue Number GTIN
      8510091000 04027269131296

      Documentation

      PyBOP SDS

      Title

      Safety Data Sheet (SDS) 

      PyBOP Certificates of Analysis

      Product Number PackagingSpecificationLot Number
      8510091000 Plastic bottlePDF Specification Document

      Brochure

      Title
      Novabiochem Coupling Reagent Flyer 2010
      Novabiochem Innovations 02/06
      Novabiochem Innovations 03/10
      Novabiochem Letters 01/14

      Citations

      Title
      • [1] J. Martinez, et al. (1985) J. Med. Chem., 28, 1874.
      • [2] J. Coste, et al. (1990) Tetrahedron Lett., 31, 205.
      • [3] G. B. Fields, et al. in 'Innovation & Perspectives in Solid Phase Synthesis, 1st International Symposium', R. Epton (Eds), SPCC UK Ltd., Birmingham, 1990, pp. 241.
      • [4] T. Høeg-Jensen, et al. (1991) Tetrahedron Lett., 32, 7617.
      • [5] R. von Eggelkraut-Gottanka, et al. (2003) Tetrahedron Lett., 44, 3551.