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520222 PPACK, Dihydrochloride - CAS 82188-90-7 - Calbiochem

PPACK, Dihydrochloride, CAS 142036-63-3, is a highly potent, selective & irreversible inhibitor of thrombin. Reacts with thrombin in a 1:1 stoichiometry. Can also inhibit tPA, Factors VIIa & XIa.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: Thrombin
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520222
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
82188-90-7C₂₁H₃₃N₆O₃•2HCl

Pricing & Availability

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520222-5MG
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      Description
      OverviewExtremely potent and selective irreversible inhibitor of thrombin (Kobs/[I] = 107M-1S-1). Reacts with thrombin in a 1:1 stoichiometry. Can also be used to inhibit tissue plasminogen activator, Factor VIIa, and Factor XIa. Also available as a 25 mM solution in H2O (Cat. No. 508773).
      Catalogue Number520222
      Brand Family Calbiochem®
      References
      ReferencesRosado, J. A., et al. 2002. J. Biol. Chem. 277, 42157.
      Odake S., et al. 1995. J. Enzyme Inhib. 9, 17.
      Arni, R.K., et al. 1993. Biochemistry 32, 4727.
      Yamashita, T., et al. 1993. Thromb. Res. 69, 93.
      Schmaier, A.H., et al. 1992. Thromb. Res. 67, 479.
      Collen, D., et al. 1982. J. Lab. Clin. Med. 99, 76.
      Kettner, C., and Shaw, E. 1981. Methods Enzymol. 80, 826.
      Kettner, C., and Shaw, E. 1979. Thromb. Res. 14, 969.
      Product Information
      CAS number82188-90-7
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₂₁H₃₃N₆O₃•2HCl
      Chemical formulaC₂₁H₃₃N₆O₃•2HCl
      Hygroscopic Hygroscopic
      ReversibleN
      Quality LevelMQ100
      Applications
      ApplicationPPACK, Dihydrochloride, CAS 142036-63-3, is a highly potent, selective & irreversible inhibitor of thrombin. Reacts with thrombin in a 1:1 stoichiometry. Can also inhibit tPA, Factors VIIa & XIa.
      Biological Information
      Primary TargetThrombin
      Primary Target IC<sub>50</sub>Kobs/[I] = 107 M⁻¹ sec⁻¹ as inhibitor of thrombin
      Purity≥80% by HPLC
      Physicochemical Information
      Cell permeableN
      Peptide SequenceH-D-Phe-Pro-Arg-chloromethylketone, 2HCl
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Protect from Moisture Protect from moisture
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions (pH <4) are stable for up to 4 months at -20°C. Rapidly decomposes at an alkaline pH.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      520222-5MG 07790788051020

      Documentation

      PPACK, Dihydrochloride - CAS 82188-90-7 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      PPACK, Dihydrochloride - CAS 82188-90-7 - Calbiochem Certificates of Analysis

      TitleLot Number
      520222

      References

      Reference overview
      Rosado, J. A., et al. 2002. J. Biol. Chem. 277, 42157.
      Odake S., et al. 1995. J. Enzyme Inhib. 9, 17.
      Arni, R.K., et al. 1993. Biochemistry 32, 4727.
      Yamashita, T., et al. 1993. Thromb. Res. 69, 93.
      Schmaier, A.H., et al. 1992. Thromb. Res. 67, 479.
      Collen, D., et al. 1982. J. Lab. Clin. Med. 99, 76.
      Kettner, C., and Shaw, E. 1981. Methods Enzymol. 80, 826.
      Kettner, C., and Shaw, E. 1979. Thromb. Res. 14, 969.

      Citations

      Title
    • Mishra, S.K., et al. 2005. Journal of Biological Chemistry 280, 19270.
      		•
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-May-2013 JSW
      DescriptionExtremely potent and selective irreversible inhibitor of thrombin (Kobs/[I] = 107M-1S-1). Reacts with thrombin in a 1:1 stoichiometry. Can also be used to inhibit tissue plasminogen activator. Factor VIIa, and Factor XIa.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number82188-90-7
      Chemical formulaC₂₁H₃₃N₆O₃•2HCl
      Peptide SequenceH-D-Phe-Pro-Arg-chloromethylketone, 2HCl
      Purity≥80% by HPLC
      SolubilityH₂O (100 mg/ml)
      Storage Protect from moisture
      Protect from light
      +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions (pH <4) are stable for up to 4 months at -20°C. Rapidly decomposes at an alkaline pH.
      Toxicity Standard Handling
      Merck USA index14, 7699
      ReferencesRosado, J. A., et al. 2002. J. Biol. Chem. 277, 42157.
      Odake S., et al. 1995. J. Enzyme Inhib. 9, 17.
      Arni, R.K., et al. 1993. Biochemistry 32, 4727.
      Yamashita, T., et al. 1993. Thromb. Res. 69, 93.
      Schmaier, A.H., et al. 1992. Thromb. Res. 67, 479.
      Collen, D., et al. 1982. J. Lab. Clin. Med. 99, 76.
      Kettner, C., and Shaw, E. 1981. Methods Enzymol. 80, 826.
      Kettner, C., and Shaw, E. 1979. Thromb. Res. 14, 969.
      Citation
    • Mishra, S.K., et al. 2005. Journal of Biological Chemistry 280, 19270.
      		•