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Buffer Detection Kit for Magnetic Beads
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491207
Sigma-AldrichNovobiocin, Sodium Salt - CAS 1476-53-5 - Calbiochem
This product can no longer be ordered through emdmillipore.com. Please refer to (Cat. No. 491207) on sigmaaldrich.com.
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Description
Overview
DNA gyrase inhibitor used for the production of positively supercoiled plasma DNA. Inhibits retrovirus RNA-dependent DNA polymerases. Also a potent inhibitor of ADP ribosylation eliminates the wild-type pMG110 plasmid from E. coli.
Catalogue Number
491207
Brand Family
Calbiochem®
References
References
Marcu, M.G., et al. 2000. J. Natl. Cancer Inst.92, 242. Luhrmann, A., et al. 1998. Antimicrob. Agents Chemotherp.42, 1911. Hooper, D.C., et al. 1984. Antimicrob. Agents Chemother. 25, 586. Lockshon, D., and Morris, D.R. 1983. Nucleic Acid. Res. 11, 2999. Sumiyoshi, Y., et al. 1983. J. Gen. Virol. 64, 2329. Staudenbauer, W.L. 1975. J. Mol. Biol. 96, 201.
Novobiocin, Sodium Salt - CAS 1476-53-5 - Calbiochem Certificates of Analysis
Title
Lot Number
491207
References
Reference overview
Marcu, M.G., et al. 2000. J. Natl. Cancer Inst.92, 242. Luhrmann, A., et al. 1998. Antimicrob. Agents Chemotherp.42, 1911. Hooper, D.C., et al. 1984. Antimicrob. Agents Chemother. 25, 586. Lockshon, D., and Morris, D.R. 1983. Nucleic Acid. Res. 11, 2999. Sumiyoshi, Y., et al. 1983. J. Gen. Virol. 64, 2329. Staudenbauer, W.L. 1975. J. Mol. Biol. 96, 201.
Data Sheet
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
22-May-2018 JSW
Description
A DNA gyrase inhibitor that can be used for the production of positively supercoiled plasma DNA. Targets the nucleotide-binding site of gyrase B. Exhibits antibacterial properties. Inhibits retrovirus RNA-dependent DNA polymerases. Inhibits LPS-induced production of pro-inflammatory cytokines. Reported to act as a potent inhibitor of ADP ribosylation. Also inhibits protein synthesis and alters the phosphorylation state of several cytosolic proteins.
Form
White to yellow solid
CAS number
1476-53-5
RTECS
RD5425000
Chemical formula
C₃₁H₃₅N₂O₁₁ · Na
Purity
≥90% by HPLC
Solubility
H₂O (50 mg/ml)
Storage
Protect from light +2°C to +8°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, refrigerate (4°C). Stock solutions are stable for 3 months at 4°C.
Toxicity
Harmful
Merck USA index
14, 6722
References
Marcu, M.G., et al. 2000. J. Natl. Cancer Inst.92, 242. Luhrmann, A., et al. 1998. Antimicrob. Agents Chemotherp.42, 1911. Hooper, D.C., et al. 1984. Antimicrob. Agents Chemother. 25, 586. Lockshon, D., and Morris, D.R. 1983. Nucleic Acid. Res. 11, 2999. Sumiyoshi, Y., et al. 1983. J. Gen. Virol. 64, 2329. Staudenbauer, W.L. 1975. J. Mol. Biol. 96, 201.
