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480010 NDSB-256 - CAS 81239-45-4 - Calbiochem

A non-detergent sulfobetaine. Reported to prevent protein aggregation and facilitate the renaturation of chemically and thermally denatured proteins.

NDSB-256 - CAS 81239-45-4 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Dimethylbenzylammonium Propane Sulfonate

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480010
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
81239-45-4C₁₂H₁₉NO₃S

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      Description
      OverviewA non-detergent sulfobetaine. Reported to prevent protein aggregation and facilitate the renaturation of chemically and thermally denatured proteins. Zwitterionic over a wide pH range. Easily removed by dialysis. At 1 M, NDSB-256 will restore 30% of the enzymatic activity of denatured egg white lysozyme; at 800 mM it will restore 16% of the enzymatic activity of denatured β-galactosidase.
      Catalogue Number480010
      Brand Family Calbiochem®
      SynonymsDimethylbenzylammonium Propane Sulfonate
      References
      ReferencesGoldberg, M.E., et al. 1996. Folding & Design 1, 21.
      Product Information
      CAS number81239-45-4
      FormWhite solid
      Hill FormulaC₁₂H₁₉NO₃S
      Chemical formulaC₁₂H₁₉NO₃S
      Hygroscopic Hygroscopic
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥99% by TLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/37/38

      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage +15°C to +30°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, store at room temperature (15-30°C). Stock solutions are stable for up to 3 months at room temperature.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      480010-25GM 07790788050610

      Documentation

      NDSB-256 - CAS 81239-45-4 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      NDSB-256 - CAS 81239-45-4 - Calbiochem Certificates of Analysis

      TitleLot Number
      480010

      References

      Reference overview
      Goldberg, M.E., et al. 1996. Folding & Design 1, 21.

      Brochure

      Title
      Biological Detergents Brochure
      Bulk Product Guide
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision02-April-2012 JSW
      SynonymsDimethylbenzylammonium Propane Sulfonate
      DescriptionA member of the class of nondetergent sulfobetaines. Unlike CHAPS and other zwittergents, NDSBs are nondenaturing even at 1 M concentrations. NDSBs have been used to improve the efficiency of solubilization of membrane proteins, to isolate nuclear proteins, to chromatographically purify halophilic proteins in low ionic strength buffers, and to crystallize proteins. They are zwitterionic over a wide pH range and do not absorb significantly in the near UV range. Reported to prevent protein aggregation and facilitate the renaturation of chemically and thermally denatured proteins. NDSBs can be easily removed by dialysis. At 1 M, NDSB-256 will restore 30% of the enzymatic activity of denatured egg white lysozyme; at 800 mM it will restore 16% of the enzymatic activity of denatured β-galactosidase.
      FormWhite solid
      CAS number81239-45-4
      Chemical formulaC₁₂H₁₉NO₃S
      Structure formulaStructure formula
      Purity≥99% by TLC
      SolubilityH₂O (200 mg/ml)
      Storage +15°C to +30°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, store at room temperature (15-30°C). Stock solutions are stable for up to 3 months at room temperature.
      Toxicity Irritant
      ReferencesGoldberg, M.E., et al. 1996. Folding & Design 1, 21.