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420119 JNK Inhibitor II - CAS 129-56-6 - Calbiochem

JNK Inhibitor II, CAS 129-56-6, is a cell-permeable, potent, selective, ATP-competitive, and reversible inhibitor of c-Jun N-terminal kinase (IC50 = 40 nM for JNK-1 & 2 & 90 nM for JNK-3).

JNK Inhibitor II - CAS 129-56-6 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Anthra[1,9-cd]pyrazol-6(2H)-one, 1,9-pyrazoloanthrone, SP600125, SAPK Inhibitor II

Primary Target: JNK 1, JNK 2, JNK 3
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420119
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Overview

Key Spec Table

CAS #Empirical Formula
129-56-6C₁₄H₈N₂O

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      Description
      OverviewA potent, cell-permeable, selective, and reversible inhibitor of c-Jun N-terminal kinase (JNK) (IC50 = 40 nM for JNK-1 and JNK-2 and 90 nM for JNK-3). The inhibition is competitive with respect to ATP. Exhibits over 300-fold greater selectivity for JNK as compared to ERK1 and p38-2 MAP kinases. Inhibits the phosphorylation of c-Jun and blocks cellular expression of IL-2, IFN-γ, TNF-α, and COX-2. Blocks IL-1-induced accumulation of phospho-Jun and induction of c-Jun transcription. A 50 mM (5 mg/454 µl) solution of JNK Inhibitor II (Cat. No. 420128) in DMSO is also available.
      Catalogue Number420119
      Brand Family Calbiochem®
      SynonymsAnthra[1,9-cd]pyrazol-6(2H)-one, 1,9-pyrazoloanthrone, SP600125, SAPK Inhibitor II
      References
      ReferencesShin, M., and Boyd, Y.D. 2002. Biochim. Biophys. Acta 1589, 311.
      Bennett, B.L., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 13681.
      Han, Z., et al. 2001. J. Clin. Invest. 108, 73.
      Product Information
      CAS number129-56-6
      ATP CompetitiveY
      FormYellowish orange solid
      Hill FormulaC₁₄H₈N₂O
      Chemical formulaC₁₄H₈N₂O
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ200
      Applications
      ApplicationJNK Inhibitor II, CAS 129-56-6, is a cell-permeable, potent, selective, ATP-competitive, and reversible inhibitor of c-Jun N-terminal kinase (IC50 = 40 nM for JNK-1 & 2 & 90 nM for JNK-3).
      Biological Information
      Primary TargetJNK 1, JNK 2, JNK 3
      Primary Target IC<sub>50</sub>40 nM for JNK-1 and JNK-2 and 90 nM for JNK-3
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Safety Information according to GHS
      RTECSCB4585000
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 2 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      420119-5MG 07790788050092