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368059 Granzyme B Substrate II, Fluorogenic - CAS 219138-02-0 - Calbiochem

A fluorogenic substrate for the detection of granzyme B and caspase-8 activity.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Z-IETD-AFC, Caspase-8 Substrate II

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368059
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368059-1MG
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      Description
      OverviewA fluorogenic substrate for the detection of granzyme B and caspase-8 activity. Reaction can be monitored visually or quantitatively by a blue to green shift in fluorescence upon cleavage of the AFC fluorophore.
      Catalogue Number368059
      Brand Family Calbiochem®
      SynonymsZ-IETD-AFC, Caspase-8 Substrate II
      References
      ReferencesKarahashi, H., and Amano, F. 2000. Biol. Pharm. Bull. 23, 140.
      Product Information
      CAS number219138-02-0
      ATP CompetitiveN
      FormWhite lyophilized solid
      Hill FormulaC₃₇H₄₂F₃N₅O₁₃
      Chemical formulaC₃₇H₄₂F₃N₅O₁₃
      ReversibleN
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetFluorogenic substrate for the detection of granzyme B and caspase-8 activity
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableN
      Emission max.
      Excitation max.
      Peptide SequenceZ-Ile-Glu-Thr-Asp-AFC
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      368059-1MG 07790788049621

      Documentation

      Granzyme B Substrate II, Fluorogenic - CAS 219138-02-0 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Granzyme B Substrate II, Fluorogenic - CAS 219138-02-0 - Calbiochem Certificates of Analysis

      TitleLot Number
      368059

      References

      Reference overview
      Karahashi, H., and Amano, F. 2000. Biol. Pharm. Bull. 23, 140.

      Brochure

      Title
      Caspases and other Apoptosis Related Tools Brochure
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision07-July-2008 RFH
      SynonymsZ-IETD-AFC, Caspase-8 Substrate II
      DescriptionA fluorogenic substrate for the detection of granzyme B. Reaction can be monitored visually or quantitatively by a blue to green shift in fluorescence upon cleavage of the AFC fluorophore (excitation maximum: ~400 nm; emission maximum: ~505 nm).
      FormWhite lyophilized solid
      CAS number219138-02-0
      Chemical formulaC₃₇H₄₂F₃N₅O₁₃
      Peptide SequenceZ-Ile-Glu-Thr-Asp-AFC
      Purity≥97% by HPLC
      SolubilityDMSO (1 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesKarahashi, H., and Amano, F. 2000. Biol. Pharm. Bull. 23, 140.