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500112 Cocarboxylase chloride

(thiamine diphosphoric acid ester chloride) EMPROVE® API

Cocarboxylase chloride MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Thiaminium diphosphoric acid ester chloride, Thiaminium pyrophosphate chloride, Thiaminium pyrophosphoric acid ester chloride, TPP

CAS #: 154-87-0 EC Number: 205-836-1 Molar Mass: 460.80 g/mol Hill Formula: C₁₂H₁₉ClN₄O₇P₂S
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500112
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Overview

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Key Spec Table

CAS #EC NumberHill FormulaMolar Mass
154-87-0205-836-1C₁₂H₁₉ClN₄O₇P₂S460.80 g/mol

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      Description
      Catalogue Number500112
      SynonymsThiaminium diphosphoric acid ester chloride, Thiaminium pyrophosphate chloride, Thiaminium pyrophosphoric acid ester chloride, TPP
      References
      Product Information
      CAS number154-87-0
      EC number205-836-1
      Hill FormulaC₁₂H₁₉ClN₄O₇P₂S
      Molar Mass460.80 g/mol
      HS Code2936 22 90
      Structure formula ImageStructure formula Image
      Quality LevelMQ600
      Applications
      Biological Information
      Physicochemical Information
      Melting Point240 - 244 °C (decomposition)
      pH value2.2 (H₂O)
      Bulk density500 kg/m3
      Solubility220 g/l
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Hazard Pictogram(s) Hazard Pictogram(s)
      Hazard Statement(s)H317: May cause an allergic skin reaction.
      Precautionary Statement(s)P261: Avoid breathing dust.
      P272: Contaminated work clothing should not be allowed out of the workplace.
      P280: Wear protective gloves.
      P302 + P352: IF ON SKIN: Wash with plenty of water.
      P333 + P313: If skin irritation or rash occurs: Get medical advice/ attention.
      P362 + P364: Take off contaminated clothing and wash it before reuse.
      Signal WordWarning
      RTECSXI7552000
      Storage class10 - 13 Other liquids and solids
      WGKWGK 1 slightly hazardous to water
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      StorageStore at +2°C to +25°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Assay (HPLC, calc. on dried substance)≥ 93.0 %
      Appearance (color)white
      Appearance (description)crystalline powder
      Identity (IR-spectrum)conforms
      Identity (Cl)passes test
      Appearance of solution (10 %; water)clear,< colour reference solution Y7
      pH-value (10 %; water)1.0 - 1.4
      Chloride (Cl) (calculated on dried substance)7.5 - 7.9 %
      Free phosphate (PO₄)≤ 1.0 %
      Sulfate (SO₄)≤ 0.01 %
      Al (Aluminium) (#)≤ 0.0010 %
      As (Arsenic)≤ 0.0003 %
      Ni (Nickel) (#)≤ 0.0002 %
      Thiamin Monophosphoric Acid Ester Chloride (HPLC)≤ 4.0 %
      Thiamin Dichloride (HPLC)≤ 0.5 %
      Dithiamine Triphosphate (HPLC)≤ 0.20 %
      Impurity A (HPLC)≤ 0.1
      Impurity B (HPLC)≤ 0.1
      Related substances (HPLC)≤ 1.5 %
      Loss on drying (130 °C)≤ 1.5 %
      Endotoxins≤ 12 I.U./g
      Microbiological testpasses test
      Colony count (aerobic bacteria (TAMC))≤ 500 CFU/g
      Colony count (Yeasts and moulds (TYMC))≤ 100 CFU/g
      Salmonella speciesIn 10g substance not detectable
      E.coliIn 1g substance not detectable
      Staphylococcus aureusIn 1g substance not detectable
      Pseudomonas aeruginosaIn 1g substance not detectable
      Candida albicansIn 1g substance not detectable
      Residual solvents (Ph Eur/USP/ICH) class 2 (Methanol)≤ 2.0 %
      Other residual solvents (Ph Eur/USP/ICH)excluded by manufacturing process
      Elemental impurity specifications have been set considering ICH Q3D (Guideline for Elemental Impurities).
      Class 1-3 elements are not likely to be present above the ICH Q3D option 1 limit, unless specified and indicated (#).
      Residues of metal or metal reagents acc. to EMEA/CHMP/SWP/ 4446/2000 are not likely to be present.
      Global Trade Item Number
      Catalogue Number GTIN
      5001125000 04022536255972

      Documentation

      Emprove® API Information Package

      Title

      Cocarboxylase chloride SDS

      Title

      Safety Data Sheet (SDS) 

      Cocarboxylase chloride Certificates of Analysis

      Product Number PackagingSpecificationLot Number
      5001125000 Plastic bottlePDF Specification Document

      Certificates

      Title

      Brochure

      Title
      Principios activos a la medida de