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218765 Caspase-9 Substrate I, Fluorogenic - CAS 210345-03-2 - Calbiochem

A fluorogenic substrate for caspase-9 (ICE-LAP6, Mch6).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Ac-LEHD-AFC

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218765
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Overview

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218765-1MG
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      Description
      OverviewA fluorogenic substrate for caspase-9 (ICE-LAP6, Mch6). May also act as a substrate for caspase-4 and caspase-5. Reaction can be monitored visually or quantitatively by a blue to green shift in fluorescence upon cleavage of the AFC fluorophore.
      Catalogue Number218765
      Brand Family Calbiochem®
      SynonymsAc-LEHD-AFC
      References
      ReferencesIto, A., et al. 1999. Biochim. Biophys. Acta 1452, 263.
      Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
      Thornberry, N.A., et al. 1997. J. Biol. Chem. 272, 17907.
      Product Information
      CAS number210345-03-2
      ATP CompetitiveN
      FormWhite solid
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₃₃H₃₈F₃N₇O₁₁
      Chemical formulaC₃₃H₃₈F₃N₇O₁₁
      ReversibleN
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetA fluorogenic substrate for caspase-9
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Emission max.
      Excitation max.
      Peptide SequenceAc-Leu-Glu-His-Asp-AFC
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Protect from Moisture Protect from moisture
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      218765-1MG 07790788060237

      Documentation

      Caspase-9 Substrate I, Fluorogenic - CAS 210345-03-2 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Caspase-9 Substrate I, Fluorogenic - CAS 210345-03-2 - Calbiochem Certificates of Analysis

      TitleLot Number
      218765

      References

      Reference overview
      Ito, A., et al. 1999. Biochim. Biophys. Acta 1452, 263.
      Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
      Thornberry, N.A., et al. 1997. J. Biol. Chem. 272, 17907.

      Brochure

      Title
      Caspases and other Apoptosis Related Tools Brochure
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision04-June-2008 RFH
      SynonymsAc-LEHD-AFC
      DescriptionA fluorogenic substrate for caspase-9 (ICE-LAP6, Mch6). Reaction can be monitored visually or quantitatively by a blue to green shift in fluorescence upon cleavage of the AFC fluorophore (excitation maximum: ~400 nm; emission maximum: ~505 nm).
      FormWhite solid
      FormulationSupplied as a trifluoroacetate salt.
      CAS number210345-03-2
      Chemical formulaC₃₃H₃₈F₃N₇O₁₁
      Peptide SequenceAc-Leu-Glu-His-Asp-AFC
      Purity≥95% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage Protect from moisture
      Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesIto, A., et al. 1999. Biochim. Biophys. Acta 1452, 263.
      Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
      Thornberry, N.A., et al. 1997. J. Biol. Chem. 272, 17907.