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220201 CHAPS, Molecular Biology Grade - CAS 75621-03-3 - Calbiochem

CAS 75621-03-3 is a zwitterionic detergent that combines features of bile salts and N-alkyl sulfobetaines.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 3-[(3-Cholamidopropyl)dimethylammonio]-1-propanesulfonate

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220201
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
75621-03-3C₃₂H₅₈N₂O₇S

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      Description
      OverviewZwitterionic detergent that combines features of bile salts and N-alkyl sulfobetaines. Better at solubilizing proteins than structurally-related carboxylic acid anions and is much more effective at breaking protein-protein interactions than either sodium cholate or TRITON® X-100 Detergent. Capable of solubilizing the opiate receptor to a state exhibiting reversible binding of opiates. Also, capable of disaggregating cytochrome P450 to its monomeric form without denaturation. Has a small micellar molecular weight and a high critical micellar concentration and can be removed from either gels or protein solutions by dialysis across a membrane. Aggregation number: 4-14.
      Conductivity (1.0 M, 24°C): <100 µmhos.
      Catalogue Number220201
      Brand Family Calbiochem®
      Synonyms3-[(3-Cholamidopropyl)dimethylammonio]-1-propanesulfonate
      References
      ReferencesChen, Y., et al. 1992. Biochemistry 31, 2415.
      Ofri, D., et al. 1992. J. Neurochem. 58, 628.
      Ransom, R.W., et al. 1992. Biochem. Pharmacol. 43, 1823.
      Simonds, W.F., et al. 1992. Proc. Natl. Acad. Sci. USA 77, 4623.
      Yannariello-Brown, J., and Weigel, P.H. 1992. Biochemistry 31, 576.
      Hjelmeland, L.M. 1980. Proc. Natl. Acad. Sci. USA 77, 6368.
      Simonds, W.F., et al. 1980. Proc. Natl. Acad. Sci. USA 77, 4623.
      Product Information
      CAS number75621-03-3
      Aggregation Number4 - 14
      CMC6 - 10 mM
      FormWhite crystalline powder
      Hill FormulaC₃₂H₅₈N₂O₇S
      Chemical formulaC₃₂H₅₈N₂O₇S
      Hygroscopic Hygroscopic
      Micellar weight6150
      Quality LevelMQ300
      Applications
      Biological Information
      Purity≥98% by NMR
      Physicochemical Information
      ContaminantsDNase, RNase, and Protease: none detected
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 22-36/38

      Harmful if swallowed.
      Irritating to eyes and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage +15°C to +30°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      220201-10GM 07790788048754

      Documentation

      CHAPS, Molecular Biology Grade - CAS 75621-03-3 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      CHAPS, Molecular Biology Grade - CAS 75621-03-3 - Calbiochem Certificates of Analysis

      TitleLot Number
      220201

      References

      Reference overview
      Chen, Y., et al. 1992. Biochemistry 31, 2415.
      Ofri, D., et al. 1992. J. Neurochem. 58, 628.
      Ransom, R.W., et al. 1992. Biochem. Pharmacol. 43, 1823.
      Simonds, W.F., et al. 1992. Proc. Natl. Acad. Sci. USA 77, 4623.
      Yannariello-Brown, J., and Weigel, P.H. 1992. Biochemistry 31, 576.
      Hjelmeland, L.M. 1980. Proc. Natl. Acad. Sci. USA 77, 6368.
      Simonds, W.F., et al. 1980. Proc. Natl. Acad. Sci. USA 77, 4623.

      Brochure

      Title
      Biological Detergents Brochure
      Bulk Product Guide
      CALBIOSORBﾙ Technical Bulletin
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision12-November-2010 RFH
      Synonyms3-[(3-Cholamidopropyl)dimethylammonio]-1-propanesulfonate
      DescriptionNon-denaturing zwitterionic detergent that combines features of bile salts and N-alkyl sulfobetaines. Better at solubilizing proteins than the structurally related carboxylic acid anions, and is more effective at breaking protein-protein interactions than either sodium cholate or TRITON® X-100. Capable of solubilizing the opiate receptor to a state exhibiting reversible binding to opiates. Also capable of disaggregating P 450 to its monomeric form without denaturation. Has a small micellar molecular weight (6150 Daltons) and a high critical micellar concentration (6-10 mM). Can be removed from either gels or protein solutions by dialysis. Aggregation number: 4-14.
      FormWhite crystalline powder
      CAS number75621-03-3
      Chemical formulaC₃₂H₅₈N₂O₇S
      Purity≥98% by NMR
      ContaminantsDNase, RNase, and Protease: none detected
      SolubilityH₂O (1.0 M)
      Storage +15°C to +30°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.
      Toxicity Harmful
      Merck USA index14, 2044
      ReferencesChen, Y., et al. 1992. Biochemistry 31, 2415.
      Ofri, D., et al. 1992. J. Neurochem. 58, 628.
      Ransom, R.W., et al. 1992. Biochem. Pharmacol. 43, 1823.
      Simonds, W.F., et al. 1992. Proc. Natl. Acad. Sci. USA 77, 4623.
      Yannariello-Brown, J., and Weigel, P.H. 1992. Biochemistry 31, 576.
      Hjelmeland, L.M. 1980. Proc. Natl. Acad. Sci. USA 77, 6368.
      Simonds, W.F., et al. 1980. Proc. Natl. Acad. Sci. USA 77, 4623.