506166 Sigma-Aldrichp53 Modulator, CP-31398 - CAS 259199-65-0 - Calbiochem
A cell-permeable styrylquinazoline compound that protects wild-type p53 against heat-induced denaturation and locks newly synthesized mutant p53 in an active conformation.
More>> A cell-permeable styrylquinazoline compound that protects wild-type p53 against heat-induced denaturation and locks newly synthesized mutant p53 in an active conformation. Less<<Synonyms: p53 Activator V, Nʹ-(2-(2-(4-Methoxyphenyl)ethenyl)-4-quinazolinyl)-N,N-dimethyl-1,3-propanediamine, 2HCl
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Overview
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Key Spec Table
| CAS # | Empirical Formula |
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| 259199-65-0 | C₂₂H₂₆N₄O • 2HCl |
| Description | |
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| Overview | This product has been discontinued. A cell-permeable styrylquinazoline compound that protects wild-type p53 against heat-induced denaturation and locks newly synthesized mutant p53 in an active conformation as determined by mAb PAb1620 (Cat. No. OP33) reactivity and DNA binding in both intact cells and in cell-free assays. Shown to induce p21WAF1 and Bax expressions and apoptosis (2.5 to 10 µg/ml) in mutant p53-carrying, but not p53-null, cells. Reported to suppress the growths of human cancer cells, A375-S2 and DLD-1, in mice (100 mg/kg/day; i.p.) and Azoxymethane-induced colorectal cancer in F344 rats (supplemented at 100 to 400 ppm in animal feed) in vivo. Unlike PRIMA-1 (Cat. No. 530050), CP-31398 directly targets the DBD (DNA binding domain) of p53. Also known to induce p53-independent cytotoxicity in cultures at concentrations above 15 µg/ml. |
| Catalogue Number | 506166 |
| Brand Family | Calbiochem® |
| Synonyms | p53 Activator V, Nʹ-(2-(2-(4-Methoxyphenyl)ethenyl)-4-quinazolinyl)-N,N-dimethyl-1,3-propanediamine, 2HCl |
| Product Information | |
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| CAS number | 259199-65-0 |
| Form | Yellow solid |
| Hill Formula | C₂₂H₂₆N₄O • 2HCl |
| Chemical formula | C₂₂H₂₆N₄O • 2HCl |
| Hygroscopic | Hygroscopic |
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| Purity | ≥90% by HPLC |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Catalogue Number | GTIN |
| 506166 | 0 |
Documentation
p53 Modulator, CP-31398 - CAS 259199-65-0 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 506166 |
References
| Reference overview |
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| Rao, C.V., et al. 2009. Cancer Res. 69, 8175. Demma, M.J., et al. 2004. J. Biol. Chem. 279, 45887. Wang, W., et al. 2003. Mol. Cell. Biol. 23, 2171. Wischhusen, J., et al. 2003. Oncogene 22, 8233. Rippin, T.M., et al. 2002. Oncogene 21, 2119. Foster, B.A., et al. 1999. Science 286, 2507. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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