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Merck

681664

Wnt Agonist I in DMSO

The Wnt Agonist I in DMSO, also referenced under CAS 853220-52-7, controls the biological activity of Wnt. This small molecule/inhibitor is primarily used for Cancer applications.

Synonym(s):

Wnt Agonist I in DMSO, 2-Amino-4-(3,4-(methylenedioxy)benzylamino)-6-(3-methoxyphenyl)pyrimidine, Wnt Pathway Activator I in DMSO, Wnt Pathway Activator I in DMSO, 2-Amino-4-(3,4-(methylenedioxy)benzylamino)-6-(3-methoxyphenyl)pyrimidine

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About This Item

Empirical Formula (Hill Notation):
C19H18N4O3
CAS Number:
853220-52-7
Molecular Weight:
350.37
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD09908087

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Product Name

Wnt Agonist I in DMSO, The Wnt Agonist I in DMSO, also referenced under CAS 853220-52-7, controls the biological activity of Wnt. This small molecule/inhibitor is primarily used for Cancer applications.

InChI

1S/C19H18N4O3/c1-24-14-4-2-3-13(8-14)15-9-18(23-19(20)22-15)21-10-12-5-6-16-17(7-12)26-11-25-16/h2-9H,10-11H2,1H3,(H3,20,21,22,23)

SMILES string

NC1=NC(NCC2=CC=C(OCO3)C3=C2)=CC(C4=CC=CC(OC)=C4)=N1

InChI key

FABQUVYDAXWUQP-UHFFFAOYSA-N

assay

≥95% (HPLC)

form

liquid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
avoid repeated freeze/thaw cycles
desiccated (hygroscopic)
protect from light

shipped in

ambient

storage temp.

−70°C

Quality Level

100

Related Categories

Biochem/physiol Actions

Cell permeable: yes
Reversible: yes

Disclaimer

Toxicity: Irritant (B)

General description

A cell-permeable, potent, and selective activator of Wnt signaling that does not inhibit the activity of GSK-3β (IC50 >60 µM). Shown to mimic the effect of Wnt and induce β-catenin and TCF (T-cell fate)-dependent transcriptional activity (EC50 = 700 nM in HEK-293T cells). Reported to cause substantial head defects during Xenopus embryonic development. The solid form of this compound (Cat. No. 681665) is also available.

Other Notes

Liu, J., et al. 2005. Angew. Chem. Int. Ed.44, 1987.

Packaging

Packaged under inert gas

Physical form

A 25 mM (2 mg/228 µL) solution of Wnt Agonist I (Cat. No. 681665) in DMSO.

Preparation Note

Following initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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