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Merck

219676

CFTR-F508del Corrector, KM11060 - CAS 774549-97-2 - Calbiochem

A cell-permeable sulfonylpiperazine compound that is shown to boost the surface expression of cellular F508del-CFTR in a time- and dose-dependent manner and help restore CFTR function in F508del-CFTR-expressing cells (Effective concentration 10 µM).

Synonym(s):

CFTR-F508del Corrector, KM11060 - CAS 774549-97-2 - Calbiochem, 7-Chloro-4-(4-((4-chlorophenyl)sulfonyl)piperazino)quinoline

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About This Item

Empirical Formula (Hill Notation):
C19H17Cl2N3O2S
CAS Number:
774549-97-2
Molecular Weight:
422.33
UNSPSC Code:
12352200
MDL number:
MFCD01524977

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Product Name

CFTR-F508del Corrector, KM11060 - CAS 774549-97-2 - Calbiochem, A cell-permeable sulfonylpiperazine compound that is shown to boost the surface expression of cellular F508del-CFTR in a time- and dose-dependent manner and help restore CFTR function in F508del-CFTR-expressing cells (Effective concentration 10 µM).

assay

≥97% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

white

solubility

DMSO: 5 mg/mL

shipped in

ambient

storage temp.

2-8°C

Quality Level

100

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Disclaimer

Toxicity: Standard Handling (A)

General description

A cell-permeable sulfonylpiperazine compound that is shown to boost the surface expression of cellular F508del-CFTR in a time- and dose-dependent manner and help restore CFTR function in F508del-CFTR-expressing cells (Effective concentration 10 µM). Evidence indicates that a correction of trafficking at the level of ER coupled with a transient increase of cellular cGMP due to PDEV (Cat. Nos. 524715 & 524738) inhibition as part of the cellular mechanism that accounts for the observed pharmacological effects of KM11060.
A cell-permeable sulfonylpiperazine compound that is shown to boost the surface expression of cellular F508del-CFTR in a time- and dose-dependent manner and help restore CFTR function in F508del-CFTR-expressing cells (Effective concentration 10 µM). Evidence indicates that a correction of trafficking at the level of ER coupled with a transient increase of cellular cGMP due to PDEV (Cat. Nos. 524715 and 524738 ) inhibition as part of the cellular mechanism that accounts for the observed pharmacological effects of KM11060.

Other Notes

Robert, R., et al. 2008. Mol. Pharmacol.73, 478.

Packaging

Packaged under inert gas

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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