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Merck

178220

Antipain, Hydrochloride

Peptidyl arginine aldehyde protease inhibitor produced by actinomycetes.

Synonym(s):

Antipain, Hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C27H44N10O6 · xHCl
CAS Number:
37682-72-7
Molecular Weight:
604.70 (free base basis)
UNSPSC Code:
12352202
NACRES:
NA.77
MDL number:
MFCD00135957

Key Documents

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Product Name

Antipain, Hydrochloride, Peptidyl arginine aldehyde protease inhibitor produced by actinomycetes.

SMILES string

[Cl-].[Cl-].N([C@@H](C(C)C)C(=O)NC(=O)[C@@H](NC(=O)NC(Cc1ccccc1)C(=O)O)CCCN=C(N)N)C(CCCN=C(N)N)C=O.[H+].[H+]

InChI

1S/C27H44N10O6.2ClH/c1-16(2)21(34-18(15-38)10-6-12-32-25(28)29)23(40)37-22(39)19(11-7-13-33-26(30)31)35-27(43)36-20(24(41)42)14-17-8-4-3-5-9-17;;/h3-5,8-9,15-16,18-21,34H,6-7,10-14H2,1-2H3,(H,41,42)(H4,28,29,32)(H4,30,31,33)(H2,35,36,43)(H,37,39,40);2*1H/t18?,19-,20?,21-;;/m0../s1

InChI key

GXQPAKIVOCLCHD-BXLPLHKWSA-N

description

RTECS - YV9350800

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)

color

white to slightly yellowish

solubility

water: 10 mg/mL

shipped in

ambient

storage temp.

2-8°C

Quality Level

100

Biochem/physiol Actions

Cell permeable: no
Primary Target
Trypsin-like serine proteases
Product does not compete with ATP.
Reversible: no
Target IC50: 300 µM against trypsin-like serine proteases, papain and some cysteine proteases

Disclaimer

Toxicity: Standard Handling (A)

General description

Effective concentration: 1-100 µM.
Peptidyl arginine aldehyde protease inhibitor produced by actinomycetes. Inhibitor of Ca2+-dependent endopeptidases. Has specificity similar to Leupeptin (Cat. No. 108975 ). Inhibits trypsin-like serine proteases, papain and some cysteine proteases (IC50 = 300 µM).

Other Notes

Lyupina, Y.V., et al. 1996. Eur. J. Pharmacol. 304, 23.
Umezawa, H. 1976. Methods Enzymol.55, 678.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 1 week at 4°C or for up to 1 month at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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