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407721 m-Iodobenzylguanidine, Hemisulfate - CAS 80663-95-2 - Calbiochem

407721
  
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      Overview

      Key Spec Table

      CAS #Empirical Formula
      80663-95-2C₈H₁₀IN₃ • 1/2H₂SO₄
      Description
      Overview

      This product has been discontinued.



      A cell-permeable norepinephrine analog that displays antiproliferative and proapoptotic properties. Reported to competitively inhibit arginine-dependent mono-ADP-ribosylation, impair mitochondrial respiration, stimulate glycolysis, and prevent terminal differentiation of skeletal myoblasts reversibly. Readily taken up by tissues rich in sympathetic neurons and neuroendocrine neoplasm via norepinephrine transporters (NET). Inhibits the phosphorylation of the Rho effector, PRK1/2 with no effect on the stimulation of MAP and PI3-kinases.

      Catalogue Number407721
      Brand Family Calbiochem®
      Synonyms3-Iodobenzylguanidine, Hemisulfate, MIBG
      References
      ReferencesYau, L., et al. 2004. Exp. Cell Res. 301, 320.
      Yau, L., et al. 2003. Eur. J. Biochem. 270, 101.
      Hopfner, M., et al. 2002. Int. J. Cancer 101, 210.
      Smets, L., et al. 1988. Leuk. Res. 12, 737.
      Product Information
      CAS number80663-95-2
      ATP CompetitiveY
      FormColorless to white solid
      Hill FormulaC₈H₁₀IN₃ • 1/2H₂SO₄
      Chemical formulaC₈H₁₀IN₃ • 1/2H₂SO₄
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Biological Information
      Primary TargetArginine-dependent mono-ADP-ribosylation
      Purity≥99% by HPLC
      Physicochemical Information
      Cell permeableY
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      407721 0