5.34347
hCNT2 Inhibitor
Synonym(s):
hCNT2 Inhibitor, 8-(4-Phenylbenzylamino)adenosine, Human Concentrative Nucleoside Transporter 2 Inhibitor
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About This Item
Empirical Formula (Hill Notation):
C23H24N6O4
CAS Number:
Molecular Weight:
448.47
UNSPSC Code:
12352200
assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
pale yellow
solubility
DMSO: 50 mg/mL
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
Primary Target
hCNT2
hCNT2
Reversible: yes
Target IC50: 640 nM in COS-7 cells
Disclaimer
Toxicity: Standard Handling (A)
General description
An aminoadenosine derivative that acts as a potent human concentrative nucleoside transporter 2 inhibitor. Dose-dependently blocks Na+-dependent inosine uptake in COS-7 cells transiently expressing hCNT2 with an IC50 of 0.64 µM. The anti conformer is suggested to be more bioactive than syn.
Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
Other Notes
Tatani, K., et al. 2015. ACS Med. Chem. Lett.6, 244.
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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