681671 Sigma-AldrichWnt Antagonist II, IWP-2 - CAS 686770-61-6 - Calbiochem
Wnt Antagonist II, IWP-2, CAS 686770-61-6, is a cell-permeable inhibitor of Wnt processing and secretion. Selectively blocks PORCN, a membrane-bound O-acyltransferase, & inhibits Wnt palmitoylatio
More>> Wnt Antagonist II, IWP-2, CAS 686770-61-6, is a cell-permeable inhibitor of Wnt processing and secretion. Selectively blocks PORCN, a membrane-bound O-acyltransferase, & inhibits Wnt palmitoylation. Less<<Synonyms: Inhibitor of Wnt Production-2, Wnt Pathway Inhibitor II, Porcn Inhibitor I
Recommended Products
-
SLM-241-B Sigma-Aldrich DMEM Complete Medium, with 2mM L-Glut, Sodium Pyruvate, and 10% FBS -
324870 Sigma-Aldrich Anti-α-Epithelial Cell Sodium Channel (20-42) Rabbit pAb -
1068882500 Sigma-Aldrich Papanicolaou's solution 2a Orange G solution (OG 6) -
105982 Millipore D(-)-Mannitol -
05-488-I-100UG Sigma-Aldrich Anti-Pyk2/CAKβ Antibody, clone 74 -
489476 Sigma-Aldrich LSD1 Inhibitor - CAS 927019-63-4 - Calbiochem -
07-618 Sigma-Aldrich Anti-SF-1 Antibody -
MABF106 Sigma-Aldrich Anti-Viperin Antibody, clone MaP.VIP
Overview
Key Spec Table
CAS # | Empirical Formula |
---|---|
686770-61-6 | C₂₂H₁₈N₄O₂S₃ |
Pricing & Availability
Catalogue Number | Availability | Packaging | Qty/Pack | Price | Quantity | |
---|---|---|---|---|---|---|
681671-10MG |
|
Plastic ampoule | 10 mg |
|
— |
Description | |
---|---|
Overview | A cell-permeable benzothiazolyl-acetamide compound that inhibits the cellular Wnt processing and secretion via selective blockage of MBOAT (membrane-bound O-acyltranferase) family member Porcn- (Porcupine) mediated Wnt palmitoylation. IWP-2 does not affect Wnt/β-catenin signaling pathway in general and, unlike IWR-1-endo (Cat. No. 681669), displays no effect against Wnt-stimulated cellular responses. Also available as a 10 mM solution in DMSO (Cat. No. 506072). |
Catalogue Number | 681671 |
Brand Family | Calbiochem® |
Synonyms | Inhibitor of Wnt Production-2, Wnt Pathway Inhibitor II, Porcn Inhibitor I |
References | |
---|---|
References | Chen, B., et al. 2009. Nature Chem. Biol. 5, 100. |
Product Information | |
---|---|
CAS number | 686770-61-6 |
Form | Off-white solid |
Hill Formula | C₂₂H₁₈N₄O₂S₃ |
Chemical formula | C₂₂H₁₈N₄O₂S₃ |
Quality Level | MQ100 |
Biological Information | |
---|---|
Purity | ≥97% by HPLC |
Packaging Information | |
---|---|
Packaged under inert gas | Packaged under inert gas |
Global Trade Item Number | |
---|---|
Catalogue Number | GTIN |
681671-10MG | 04055977225198 |