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681671 Wnt Antagonist II, IWP-2 - CAS 686770-61-6 - Calbiochem

Wnt Antagonist II, IWP-2, CAS 686770-61-6, is a cell-permeable inhibitor of Wnt processing and secretion. Selectively blocks PORCN, a membrane-bound O-acyltransferase, & inhibits Wnt palmitoylatio

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Synonyms: Inhibitor of Wnt Production-2, Wnt Pathway Inhibitor II, Porcn Inhibitor I

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681671
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Overview

Key Spec Table

CAS #Empirical Formula
686770-61-6C₂₂H₁₈N₄O₂S₃

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681671-10MG
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      Description
      OverviewA cell-permeable benzothiazolyl-acetamide compound that inhibits the cellular Wnt processing and secretion via selective blockage of MBOAT (membrane-bound O-acyltranferase) family member Porcn- (Porcupine) mediated Wnt palmitoylation. IWP-2 does not affect Wnt/β-catenin signaling pathway in general and, unlike IWR-1-endo (Cat. No. 681669), displays no effect against Wnt-stimulated cellular responses. Also available as a 10 mM solution in DMSO (Cat. No. 506072).
      Catalogue Number681671
      Brand Family Calbiochem®
      SynonymsInhibitor of Wnt Production-2, Wnt Pathway Inhibitor II, Porcn Inhibitor I
      References
      ReferencesChen, B., et al. 2009. Nature Chem. Biol. 5, 100.
      Product Information
      CAS number686770-61-6
      FormOff-white solid
      Hill FormulaC₂₂H₁₈N₄O₂S₃
      Chemical formulaC₂₂H₁₈N₄O₂S₃
      Quality LevelMQ100
      Applications
      ApplicationWnt Antagonist II, IWP-2, CAS 686770-61-6, is a cell-permeable inhibitor of Wnt processing and secretion. Selectively blocks PORCN, a membrane-bound O-acyltransferase, & inhibits Wnt palmitoylation.
      Biological Information
      Purity≥97% by HPLC
      Safety Information
      R PhraseR: 20/21/22

      Harmful by inhalation, in contact with skin and if swallowed.
      S PhraseS: 22-24/25-36-45

      Do not breathe dust.
      Avoid contact with skin and eyes.
      Wear suitable protective clothing.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      681671-10MG 04055977225198