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616458 TGF-β RI Kinase Inhibitor VII - CAS 666729-57-3 - Calbiochem

The TGF-β RI Kinase Inhibitor VII, also referenced under CAS 666729-57-3, controls the biological activity of TGF-β RI Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 1-(2-((6,7-Dimethoxy-4-quinolyl)oxy)-(4,5-dimethylphenyl)-1-ethanone, ALK5 Inhibitor VII

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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      666729-57-3C₂₁H₂₁NO₄
      Description
      Overview

      This product has been discontinued.



      A cell-permeable quinoline compound that acts a potent ATP-competitive inhibitor of ALK5/TGF-β Receptor I kinase activity (IC50 = 0.63 µM), while inhibiting c-Src only at higher concentrations (IC50 = 13 µM). Shown to block TGF-β-induced Smad2 phosphorylation and Smad2/3 transcription activity (IC50 = 0.5 and 0.37 µM, respectively) in human lung cancer epithelial cell line A549.
      Catalogue Number616458
      Brand Family Calbiochem®
      Synonyms1-(2-((6,7-Dimethoxy-4-quinolyl)oxy)-(4,5-dimethylphenyl)-1-ethanone, ALK5 Inhibitor VII
      References
      ReferencesShimizu, T., et al. 2008. J. Med. Chem. 51, 3326.
      Product Information
      CAS number666729-57-3
      FormOff-white solid
      Hill FormulaC₂₁H₂₁NO₄
      Chemical formulaC₂₁H₂₁NO₄
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥97% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 20/21/22

      Harmful by inhalation, in contact with skin and if swallowed.
      S PhraseS: 22-24/25-36-45

      Do not breathe dust.
      Avoid contact with skin and eyes.
      Wear suitable protective clothing.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      616458 0

      Documentation

      TGF-β RI Kinase Inhibitor VII - CAS 666729-57-3 - Calbiochem Certificates of Analysis

      TitleLot Number
      616458

      References

      Reference overview
      Shimizu, T., et al. 2008. J. Med. Chem. 51, 3326.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-April-2011 RFH
      Synonyms1-(2-((6,7-Dimethoxy-4-quinolyl)oxy)-(4,5-dimethylphenyl)-1-ethanone, ALK5 Inhibitor VII
      DescriptionA cell-permeable quinoline compound that acts a potent ATP-competitive inhibitor of ALK5/TGF-β Receptor I kinase activity (IC50 = 0.63 µM), while inhibiting c-Src only at higher concentrations (IC50 = 13 µM). Shown to block TGF-β-induced Smad2 phosphorylation and Smad2/3 transcription activity (IC50 = 0.5 and 0.37 µM, respectively) in human lung cancer epithelial cell line A549.
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number666729-57-3
      Chemical formulaC₂₁H₂₁NO₄
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (10 mg/ml) or Ethanol (2 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Harmful
      ReferencesShimizu, T., et al. 2008. J. Med. Chem. 51, 3326.