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530959 TAZ Activity Modulator, TM-25659 - CAS 260553-97-7 - Calbiochem

A cell-permeable enhancer of nuclear localization of transcriptional co-activator with PDZ-binding motif (TAZ). Does not affect the total amount of TAZ in pluripotent C3H10T1/2 cells.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: TM25659, TM 25659

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530959
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
260553-97-7C₃₀H₂₈N₈

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      Description
      OverviewA cell permeable, orally bioavailable imidazol-[4,5-b]pyridine derivative that enhances nuclear localization of transcriptional co-activator with PDZ-binding motif (TAZ) in a dose-dependent manner without affecting the total amount of TAZ in pluripotent C3H10T1/2 cells. Does not affect Ser89 phosphorylation in TAZ, but reduces tyrosine phosphorylation. Reduces PPARg levels in differentiated adipocytes and acts as a suppressor of PPARg-dependent adipocyte differentiation. Also shown to enhance RUNX2-induced osteoblast differentiation of C3H10T1/2 cells and mineralization in a dose-dependent manner. Reduces weight gain in ob/ob mice (50 mg/kg, i.p.) and attenuates bone loss in ovariectomized mice. Displays desirable pharmacokinetic properties with t1/2 = 9.85 h.

      Please note that the molecular weight for this compound is batch-specific due to variable water content.
      Catalogue Number530959
      Brand Family Calbiochem®
      SynonymsTM25659, TM 25659
      References
      ReferencesJang, E.J., et al. 2012. Br. J. Pharmacol. 165, 1584.
      Product Information
      CAS number260553-97-7
      FormYellow powder
      Hill FormulaC₃₀H₂₈N₈
      Chemical formulaC₃₀H₂₈N₈
      ReversibleY
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      5.30959.0001 04055977283259

      Documentation

      TAZ Activity Modulator, TM-25659 - CAS 260553-97-7 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Jang, E.J., et al. 2012. Br. J. Pharmacol. 165, 1584.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision15-March-2015 JSW
      SynonymsTM25659, TM 25659
      DescriptionA cell permeable, orally bioavailable imidazol-pyrimidine derivative that enhances nuclear localization of transcriptional co-activator with PDZ-binding motif (TAZ) in a dose-dependent manner without affecting the total amount of TAZ in pluripotent C3H10T1/2 cells. Does not affect Ser89 phosphorylation in TAZ, but reduces tyrosine phosphorylation. Reduces PPARg levels in differentiated adipocytes and acts as a suppressor of PPARg-dependent adipocyte differentiation. Also shown to enhance RUNX2-induced osteoblast differentiation of C3H10T1/2 cells and mineralization in a dose-dependent manner. Reduces weight gain in ob/ob mice (50 mg/kg, i.p.) and attenuates bone loss in ovariectomized mice. Displays desirable pharmacokinetic properties with t1/2 = 9.85 h.
      FormYellow powder
      Intert gas (Yes/No) Packaged under inert gas
      CAS number260553-97-7
      Chemical formulaC₃₀H₂₈N₈
      Purity≥97% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesJang, E.J., et al. 2012. Br. J. Pharmacol. 165, 1584.