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567630 Sodium Salicylate - CAS 54-21-7 - Calbiochem

A cell-permeable, non-steroidal anti-inflammatory agent that interferes with TNF-induced NF-κB activation by inhibiting phosphorylation and subsequent degradation of the IκB-α protein.

Sodium Salicylate - CAS 54-21-7 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Salicylic Acid, Na, NaSal

Primary Target: TNF-induced activation of p42 (ERK2) and p44 (ERK1) MAP kinases
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567630
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
54-21-7C₇H₅O₃ · Na

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      Description
      OverviewA cell-permeable, non-steroidal anti-inflammatory agent that interferes with TNF-induced NF-κB activation by inhibiting phosphorylation and subsequent degradation of the IκB-α protein. Selectively inhibits TNF-induced activation of p42 (ERK2) and p44 (ERK1) MAP kinases. Also inhibits TNF-induced activation of JNK. Induces apoptosis via p38 kinase activation. Inhibits COX-2 and inducible NOS (iNOS) transcription independently of NF-κB activation.
      Catalogue Number567630
      Brand Family Calbiochem®
      SynonymsSalicylic Acid, Na, NaSal
      References
      ReferencesSchwenger, P., et al. 1998. Mol. Cell. Biol. 18, 78.
      Mitchell, J.A., et al. 1997. Mol. Pharmacol. 51, 907.
      Schwenger, P., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 2869.
      Farivar, R.S. and Brecher, P. 1996. J. Biol. Chem. 271, 31585.
      Schwenger, P., et al. 1996. J. Biol. Chem. 271, 8089.
      Product Information
      CAS number54-21-7
      ATP CompetitiveN
      FormOff-white solid
      Hill FormulaC₇H₅O₃ · Na
      Chemical formulaC₇H₅O₃ · Na
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetTNF-induced activation of p42 (ERK2) and p44 (ERK1) MAP kinases
      Purity≥98% by titration
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSVO5075000
      Safety Information
      R PhraseR: 22

      Harmful if swallowed.
      S PhraseS: 24/25

      Avoid contact with skin and eyes.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage +15°C to +30°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      567630-5GM 04055977266825

      Documentation

      Sodium Salicylate - CAS 54-21-7 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Sodium Salicylate - CAS 54-21-7 - Calbiochem Certificates of Analysis

      TitleLot Number
      567630

      References

      Reference overview
      Schwenger, P., et al. 1998. Mol. Cell. Biol. 18, 78.
      Mitchell, J.A., et al. 1997. Mol. Pharmacol. 51, 907.
      Schwenger, P., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 2869.
      Farivar, R.S. and Brecher, P. 1996. J. Biol. Chem. 271, 31585.
      Schwenger, P., et al. 1996. J. Biol. Chem. 271, 8089.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-May-2008 RFH
      SynonymsSalicylic Acid, Na, NaSal
      DescriptionA non-steroidal, anti-inflammatory drug that interferes with TNF-induced NF-κB activation by inhibiting phosphorylation and subsequent degradation of the IκB-α protein. Selectively inhibits TNF-induced activation of p42 (ERK2) and p44 (ERK1) MAP kinases. Also inhibits TNF-induced activation of JNK. Induces apoptosis via p38 kinase activation. Inhibits COX-2 and inducible NOS (iNOS) transcription independently of NF-κB activation.
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number54-21-7
      RTECSVO5075000
      Chemical formulaC₇H₅O₃ · Na
      Structure formulaStructure formula
      Purity≥98% by titration
      SolubilityEthanol or H₂O (50 mg/ml)
      Storage +15°C to +30°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Harmful
      Merck USA index14, 8332
      ReferencesSchwenger, P., et al. 1998. Mol. Cell. Biol. 18, 78.
      Mitchell, J.A., et al. 1997. Mol. Pharmacol. 51, 907.
      Schwenger, P., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 2869.
      Farivar, R.S. and Brecher, P. 1996. J. Biol. Chem. 271, 31585.
      Schwenger, P., et al. 1996. J. Biol. Chem. 271, 8089.