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567020 Simvastatin - CAS 79902-63-9 - Calbiochem

A lipophilic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that blocks Ras function through inhibition of farnesylation.

Simvastatin - CAS 79902-63-9 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: MK-733, L-Type Calcium Channel Blocker VI

Primary Target: farnesylation
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567020
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Overview

Key Spec Table

CAS #Empirical Formula
79902-63-9C₂₅H₃₈O₅

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567020-50MG
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      Description
      OverviewA lipophilic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that blocks Ras function through inhibition of farnesylation. Also inhibits glucose-induced Ca2+ signaling and insulin secretion by blocking L-type Ca2+ channels in rat islet β-cells. Inhibits cell proliferation of human smooth muscle cells. Note: this product is supplied in an inactive form and requires treatment with NaOH in EtOH followed by neutralization to pH 7.2 for activation.
      Catalogue Number567020
      Brand Family Calbiochem®
      SynonymsMK-733, L-Type Calcium Channel Blocker VI
      References
      ReferencesYada, T., et al. 1999. Br. J. Pharmacol. 126, 1205.
      Clutterbuck, R.D., et al. 1998. Br. J. Haematol. 102, 522.
      Yokoyama, K., et al. 1998. Mol. Biochem. Parasitol. 94, 87.
      Negre-Aminou, P., et al. 1997. Biochim. Biophys. Acta 1345, 259.
      Vrtovsnik, F., et al. 1997. Kidney Int. 52, 1016.
      Keyomarsi, K., et al. 1991. Cancer Res. 51, 3602.
      Product Information
      CAS number79902-63-9
      ATP CompetitiveN
      FormOff-white solid
      Hill FormulaC₂₅H₃₈O₅
      Chemical formulaC₂₅H₃₈O₅
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary Targetfarnesylation
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableN
      ContaminantsHeavy metals: <20 ppm
      Heavy metals≤20 ppm
      Safety Information according to GHS
      RTECSEK7798000
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution in ethanol-NaOH, aliquot and freeze (-20°C) Ethanol-NaOH solutions are stable for up to 1 month at -20°C. Neutralized solutions should be used immediately.
      Global Trade Item Number
      Catalogue Number GTIN
      567020-50MG 04055977267099