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553031 RAGE Antagonist Peptide, RAP - Calbiochem

Overview

Key Spec Table

Empirical Formula
C₅₇H₁₀₁N₁₃O₁₇S

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553031-10MG
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      Glass bottle 10 mg
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      Description
      OverviewAn S100P-derived peptide based competitive antagonist for receptor for advanced glycation end product (RAGE). Shown to disrupt the interaction between RAGE and its ligands, such as S100P, S100A4 and HMGB-1 in binding assays and in multiple cancer cell lines (~2 µM). Also, blocks RAGE-dependent NF-kB activation in MPanc96, MOH and HPAF II tumor cell lines. Systemic administration of RAP also diminishes NF-kB signaling in vivo and significantly reduces glioma tumor growth in murine models.
      Catalogue Number553031
      Brand Family Calbiochem®
      SynonymsELKVLMEKEL
      References
      ReferencesArumugam, T., et al. 2012. Clin Cancer Res. 18, 4356.
      Product Information
      FormWhite powder
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₅₇H₁₀₁N₁₃O₁₇S
      ReversibleY
      Quality LevelMQ200
      Biological Information
      Primary TargetRAGE
      Primary Target IC<sub>50</sub>2 µ
      Purity≥95% by HPLC
      Physicochemical Information
      Peptide SequenceAc-ELKVLMEKEL-NH2
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      553031-10MG 04055977193473