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580555 Paclitaxel, Taxus sp. - CAS 33069-62-4 - Calbiochem

Antitumor and antileukemic agent isolated from the bark of the yew tree.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Baccatin III N-benzyl-β-phenylisoserine Ester, TAXOL®

Primary Target: Promotes assembly of microtubules and inhibits tubulins disassembly
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
33069-62-4C₄₇H₅₁NO₁₄

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      580555-25MG
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          580555-5MG
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              Description
              OverviewAntitumor and antileukemic agent isolated from the bark of the yew tree. Promotes assembly of microtubules and inhibits tubulin disassembly. An effective agent in blocking HeLa and B16 cells at the G2/M stage. Inhibits DNA synthesis and stimulates the release of tumor necrosis factor-α. Induces apoptosis in murine mammary carcinoma MCA-4 and ovarian carcinoma OCA-1 tumors.
              Catalogue Number580555
              Brand Family Calbiochem®
              SynonymsBaccatin III N-benzyl-β-phenylisoserine Ester, TAXOL®
              References
              ReferencesDerry, W.B., et al. 1995. Biochemistry 34, 2203.
              Milas, L., et al. 1995. Cancer Chemother. Pharmacol. 35, 297.
              Donaldson, K.L., et al. 1994. Int. J. Cancer 57, 847.
              Hornback, N.B., et al. 1994. In Vivo 8, 819.
              Manthey, C.L., et al. 1992. J. Immunol. 149, 2459.
              Rowinsky, E.K., et al. 1992. Semin. Oncol.19, 646.
              Ding, A.H., et al. 1990. Science 248, 370.
              Mogensen, M.M. and Tucker, J.B. 1990. J. Cell Sci. 97, 101.
              Slichenmeyer, W.J. and Von Hoff, D.D. 1990. J. Clin. Pharmacol. 30, 770.
              Product Information
              CAS number33069-62-4
              ATP CompetitiveN
              FormWhite solid
              Hill FormulaC₄₇H₅₁NO₁₄
              Chemical formulaC₄₇H₅₁NO₁₄
              ReversibleN
              Structure formula ImageStructure formula Image
              Quality LevelMQ100
              Applications
              Biological Information
              Primary TargetPromotes assembly of microtubules and inhibits tubulins disassembly
              Purity≥97% by HPLC
              Physicochemical Information
              Cell permeableN
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              RTECSDA8340700
              Safety Information
              R PhraseR: 37/38-41-46-60

              Irritating to respiratory system and skin.
              Risk of serious damage to eyes.
              May cause heritable genetic damage.
              May impair fertility.
              S PhraseS: 22-26-36/37/39-45

              Do not breathe dust.
              In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
              Wear suitable protective clothing, gloves and eye/face protection.
              In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Carcinogenic / Teratogenic
              Storage -20°C
              Protect from Light Protect from light
              Protect from Moisture Protect from moisture
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
              Packaging Information
              Transport Information
              Supplemental Information
              Specifications
              Global Trade Item Number
              Catalogue Number GTIN
              580555-100MG 04055977265507
              580555-25MG 04055977265514
              580555-5MG 04055977265521

              Documentation

              Paclitaxel, Taxus sp. - CAS 33069-62-4 - Calbiochem SDS

              Title

              Safety Data Sheet (SDS) 

              Paclitaxel, Taxus sp. - CAS 33069-62-4 - Calbiochem Certificates of Analysis

              TitleLot Number
              580555

              References

              Reference overview
              Derry, W.B., et al. 1995. Biochemistry 34, 2203.
              Milas, L., et al. 1995. Cancer Chemother. Pharmacol. 35, 297.
              Donaldson, K.L., et al. 1994. Int. J. Cancer 57, 847.
              Hornback, N.B., et al. 1994. In Vivo 8, 819.
              Manthey, C.L., et al. 1992. J. Immunol. 149, 2459.
              Rowinsky, E.K., et al. 1992. Semin. Oncol.19, 646.
              Ding, A.H., et al. 1990. Science 248, 370.
              Mogensen, M.M. and Tucker, J.B. 1990. J. Cell Sci. 97, 101.
              Slichenmeyer, W.J. and Von Hoff, D.D. 1990. J. Clin. Pharmacol. 30, 770.
              Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision19-May-2008 RFH
              SynonymsBaccatin III N-benzyl-β-phenylisoserine Ester, TAXOL®
              DescriptionAntitumor and anti-leukemic agent isolated from the bark of the yew tree. Promotes assembly of microtubules and inhibits tubulin disassembly. An effective agent in blocking HeLa and B16 cells at the G2/M stage. Inhibits DNA synthesis and stimulates the release of tumor necrosis factor-α. Induces apoptosis in murine mammary carcinoma MCA-4 and ovarian carcinoma OCA-1 tumors.
              FormWhite solid
              CAS number33069-62-4
              RTECSDA8340700
              Chemical formulaC₄₇H₅₁NO₁₄
              Structure formulaStructure formula
              Purity≥97% by HPLC
              SolubilityDMSO (10 mg/ml) or Methanol (1 mg/ml)
              Storage Protect from moisture
              Protect from light
              -20°C
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
              Toxicity Carcinogenic / Teratogenic
              Merck USA index14, 6982
              ReferencesDerry, W.B., et al. 1995. Biochemistry 34, 2203.
              Milas, L., et al. 1995. Cancer Chemother. Pharmacol. 35, 297.
              Donaldson, K.L., et al. 1994. Int. J. Cancer 57, 847.
              Hornback, N.B., et al. 1994. In Vivo 8, 819.
              Manthey, C.L., et al. 1992. J. Immunol. 149, 2459.
              Rowinsky, E.K., et al. 1992. Semin. Oncol.19, 646.
              Ding, A.H., et al. 1990. Science 248, 370.
              Mogensen, M.M. and Tucker, J.B. 1990. J. Cell Sci. 97, 101.
              Slichenmeyer, W.J. and Von Hoff, D.D. 1990. J. Clin. Pharmacol. 30, 770.

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              Categories

              Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Extracellular Matrix, Adhesion and Cytoskeletal Research Tools