539741 Sigma-AldrichPTP1B Inhibitor - CAS 765317-72-4 - Calbiochem
PTP1B Inhibitor, CAS 765317-72-4, is a cell-permeable, selective, reversible and non-competitive allosteric inhibitor of PTP1B (IC₅₀ = 4 µM and 8 µM for PTP1B403 and PTP1B298, respectively).
More>> PTP1B Inhibitor, CAS 765317-72-4, is a cell-permeable, selective, reversible and non-competitive allosteric inhibitor of PTP1B (IC₅₀ = 4 µM and 8 µM for PTP1B403 and PTP1B298, respectively). Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: 3-(3,5-Dibromo-4-hydroxy-benzoyl)-2-ethyl-benzofuran-6-sulfonicacid-(4-(thiazol-2-ylsulfamyl)-phenyl)-amide, PTP Inhibitor XXII
Recommended Products
-
NY3004700 Millipore Nylon Net Filter -
ST1137 Anti-FOXP3 Mouse mAb (3G3) -
SLHV033RB Millipore Millex®-HV Filter Unit (Sterile) -
ABN417 Sigma-Aldrich Anti-ORMDL3 Antibody -
MABE2036-25UG Sigma-Aldrich Anti-PADI2/PAD2 Antibody, clone DN2 -
VSERVSPEC BioReliance Non-Standard Bacterial Retention Testing -
CDUFBI001 Milli-Q Biopak® Polisher -
105398 Millipore Malt extract agar -
MABN629 Sigma-Aldrich Anti-PPID Antibody, clone 6A5.1
Overview
Key Spec Table
| CAS # | Empirical Formula |
|---|---|
| 765317-72-4 | C₂₆H₁₉Br₂N₃O₇S₃ |
Pricing & Availability
| Catalogue Number | Availability | Packaging | Qty/Pack | Price | Quantity | |
|---|---|---|---|---|---|---|
| 539741-5MG |
|
Plastic ampoule | 5 mg |
|
— |
| Description | |
|---|---|
| Overview | A cell-permeable sulfanamido-benzbromarone compound that acts as a selective, reversible and non-competitive allosteric inhibitor of PTP1B (IC50 = 4 µM and 8 µM for PTP1B403 and PTP1B298, respectively). Binds to a novel site away from the catalytic pocket and inhibits PTP1B activity by preventing closure of the WPD loop. Also available in InSolution™ format (Cat. No. 539749). |
| Catalogue Number | 539741 |
| Brand Family | Calbiochem® |
| Synonyms | 3-(3,5-Dibromo-4-hydroxy-benzoyl)-2-ethyl-benzofuran-6-sulfonicacid-(4-(thiazol-2-ylsulfamyl)-phenyl)-amide, PTP Inhibitor XXII |
| References | |
|---|---|
| References | Wiesmann, C., et al. 2004. Nat. Struct. Mol. Biol. 11, 730. |
| Product Information | |
|---|---|
| CAS number | 765317-72-4 |
| ATP Competitive | N |
| Form | White solid |
| Hill Formula | C₂₆H₁₉Br₂N₃O₇S₃ |
| Chemical formula | C₂₆H₁₉Br₂N₃O₇S₃ |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ100 |
| Biological Information | |
|---|---|
| Primary Target | PTP1B403 |
| Primary Target IC<sub>50</sub> | 4 µM and 8 µM for PTP1B403 and PTP1B298, respectively |
| Purity | ≥95% by HPLC |
| Physicochemical Information | |
|---|---|
| Cell permeable | Y |
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Global Trade Item Number | |
|---|---|
| Catalogue Number | GTIN |
| 539741-5MG | 04055977194302 |