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539510 PP2A₂, Bovine Kidney

539510
  
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      Overview

      Description
      OverviewNative, PP2A2 from bovine kidney. A divalent cation-independent protein serine/threonine phosphatase involved in the control of numerous cellular processes. Has a catalytic subunit of 36 kDa and a regulatory subunit of 60 kDa. Transient phosphorylation of the catalytic subunit on threonine or tyrosine residues has been reported to inactivate PP2A2. Inhibits nuclear telomerase activity in human breast cancer cells.

      This product has been discontinued.





      Catalogue Number539510
      Brand Family Calbiochem®
      SynonymsProtein Phosphatase 2A₂
      References
      ReferencesLi, H., et al. 1997. J. Biol. Chem. 272, 16729.
      Guo, H. and Damuni, Z. 1993. Proc. Natl. Acad. Sci. USA 90, 2500.
      Hendrix, P., et al. 1993. J. Biol. Chem. 268, 15267.
      Amick, G.D., et al. 1992. Biochem. J. 287, 1019.
      Chen, J., et al. 1992. Science 257, 1261.
      Cohen, P., et al. 1990. Trends Biochem. Sci. 15, 98.
      Damuni, Z., et al. 1989. J. Biol. Chem. 264, 6412.
      Product Information
      Unit of DefinitionOne unit is defined as the amount of enzyme that will release 1.0 nmol of [³²P]P<sub>i</sub> from ³²P-labeled phosphorylase per min at 30°C, pH 7.0.
      EC number3.1.3.16
      FormLiquid
      FormulationIn 25 mM Tris-HCl, 14 mM βME, 1 mM benzamidine, 100 µM EDTA, 100 µM PMSF, 50% glycerol, pH 7.0.
      Biological Information
      Purity≥90% by SDS-PAGE
      Specific Activity≥750 units/mg
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Global Trade Item Number
      Catalogue Number GTIN
      539510 0