529581 Sigma-AldrichPP1 Analog II, 1NM-PP1 - CAS 221244-14-0 - Calbiochem
PP1 Analog II, CAS 221244-14-0, is a cell-permeable PP1 analog that acts as a potent, reversible, selective, ATP-competitive inhibitor of mutant over wild-type kinases.
More>> PP1 Analog II, CAS 221244-14-0, is a cell-permeable PP1 analog that acts as a potent, reversible, selective, ATP-competitive inhibitor of mutant over wild-type kinases. Less<<Synonyms: Mutant Kinases Inhibitor II, 4-Amino-1-tert-butyl-3-(1ʹ-naphthylmethyl)pyrazolo[3,4-d]pyrimidine, NM
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Overview
Key Spec Table
CAS # | Empirical Formula |
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221244-14-0 | C₂₀H₂₁N₅ |
Pricing & Availability
Catalogue Number | Availability | Packaging | Qty/Pack | Price | Quantity | |
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529581-1MG |
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Glass bottle | 1 mg |
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Description | |
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Overview | A cell-permeable and reversible PP1 analog (Cat. No. 529579) that acts as a potent and selective ATP-competitive inhibitor of mutant kinases over wild-type (IC50 = 3.2 nM for T339G, c-Fyn-as1 vs. 1.0 µM for c-Fyn; 4.3 nM for I338G, v-src-as1 vs. 28 µM for v-src; 5 nM for F80G, CDK2-as1 vs. 29 µM for CDK2; 8 nM for F89G, CAMK IIα-as1 vs. 24 µM for CAMKII; 120 nM for T315A, c-Abl-as2 vs. 3.4 µM for c-Abl). Shown to activate mutants of Ire1, a transmembrane kinase. Also available as a 10 mM solution in DMSO (Cat. No. 529606). |
Catalogue Number | 529581 |
Brand Family | Calbiochem® |
Synonyms | Mutant Kinases Inhibitor II, 4-Amino-1-tert-butyl-3-(1ʹ-naphthylmethyl)pyrazolo[3,4-d]pyrimidine, NM |
Product Information | |
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CAS number | 221244-14-0 |
ATP Competitive | Y |
Form | White solid |
Hill Formula | C₂₀H₂₁N₅ |
Chemical formula | C₂₀H₂₁N₅ |
Reversible | Y |
Structure formula Image | |
Quality Level | MQ100 |
Physicochemical Information | |
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Cell permeable | Y |
Packaging Information | |
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Packaged under inert gas | Packaged under inert gas |
Global Trade Item Number | |
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Catalogue Number | GTIN |
529581-1MG | 04055977269871 |