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491207 Novobiocin, Sodium Salt - CAS 1476-53-5 - Calbiochem

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MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: retrovirus RNA-dependent DNA polymerases
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491207
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
1476-53-5C₃₁H₃₅N₂O₁₁ · Na

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491207-10GM
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      Description
      OverviewDNA gyrase inhibitor used for the production of positively supercoiled plasma DNA. Inhibits retrovirus RNA-dependent DNA polymerases. Also a potent inhibitor of ADP ribosylation eliminates the wild-type pMG110 plasmid from E. coli.
      Catalogue Number491207
      Brand Family Calbiochem®
      References
      ReferencesMarcu, M.G., et al. 2000. J. Natl. Cancer Inst. 92, 242.
      Luhrmann, A., et al. 1998. Antimicrob. Agents Chemotherp. 42, 1911.
      Hooper, D.C., et al. 1984. Antimicrob. Agents Chemother. 25, 586.
      Lockshon, D., and Morris, D.R. 1983. Nucleic Acid. Res. 11, 2999.
      Sumiyoshi, Y., et al. 1983. J. Gen. Virol. 64, 2329.
      Staudenbauer, W.L. 1975. J. Mol. Biol. 96, 201.
      Product Information
      CAS number1476-53-5
      ATP CompetitiveN
      FormWhite to yellow solid
      Hill FormulaC₃₁H₃₅N₂O₁₁ · Na
      Chemical formulaC₃₁H₃₅N₂O₁₁ · Na
      ReversibleN
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetretrovirus RNA-dependent DNA polymerases
      Purity≥90% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSRD5425000
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, refrigerate (4°C). Stock solutions are stable for 3 months at 4°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      491207-10GM 07790788050818

      Documentation

      Novobiocin, Sodium Salt - CAS 1476-53-5 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Novobiocin, Sodium Salt - CAS 1476-53-5 - Calbiochem Certificates of Analysis

      TitleLot Number
      491207

      References

      Reference overview
      Marcu, M.G., et al. 2000. J. Natl. Cancer Inst. 92, 242.
      Luhrmann, A., et al. 1998. Antimicrob. Agents Chemotherp. 42, 1911.
      Hooper, D.C., et al. 1984. Antimicrob. Agents Chemother. 25, 586.
      Lockshon, D., and Morris, D.R. 1983. Nucleic Acid. Res. 11, 2999.
      Sumiyoshi, Y., et al. 1983. J. Gen. Virol. 64, 2329.
      Staudenbauer, W.L. 1975. J. Mol. Biol. 96, 201.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision22-May-2018 JSW
      DescriptionA DNA gyrase inhibitor that can be used for the production of positively supercoiled plasma DNA. Targets the nucleotide-binding site of gyrase B. Exhibits antibacterial properties. Inhibits retrovirus RNA-dependent DNA polymerases. Inhibits LPS-induced production of pro-inflammatory cytokines. Reported to act as a potent inhibitor of ADP ribosylation. Also inhibits protein synthesis and alters the phosphorylation state of several cytosolic proteins.
      FormWhite to yellow solid
      CAS number1476-53-5
      RTECSRD5425000
      Chemical formulaC₃₁H₃₅N₂O₁₁ · Na
      Purity≥90% by HPLC
      SolubilityH₂O (50 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, refrigerate (4°C). Stock solutions are stable for 3 months at 4°C.
      Toxicity Harmful
      Merck USA index14, 6722
      ReferencesMarcu, M.G., et al. 2000. J. Natl. Cancer Inst. 92, 242.
      Luhrmann, A., et al. 1998. Antimicrob. Agents Chemotherp. 42, 1911.
      Hooper, D.C., et al. 1984. Antimicrob. Agents Chemother. 25, 586.
      Lockshon, D., and Morris, D.R. 1983. Nucleic Acid. Res. 11, 2999.
      Sumiyoshi, Y., et al. 1983. J. Gen. Virol. 64, 2329.
      Staudenbauer, W.L. 1975. J. Mol. Biol. 96, 201.

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      Categories

      Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Cell Cycle/Cell Division > DNA and RNA Polymerase Inhibitors