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500299 Nicotinamide

EMPROVE® ESSENTIAL Ph Eur,BP,USP,JP,FCC

Nicotinamide MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Nicotinamide, Niacinamide, 3-Pyridinecarboxamide

CAS #: 98-92-0 EC Number: 202-713-4 Molar Mass: 122.13 g/mol Hill Formula: C₆H₆N₂O Grade: Ph Eur,BP,USP,JP,FCC
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Overview

Key Spec Table

CAS #EC NumberHill FormulaMolar MassGrade Value
98-92-0202-713-4C₆H₆N₂O122.13 g/molPh Eur,BP,USP,JP,FCC

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      Description
      Catalogue Number500299
      SynonymsNicotinamide, Niacinamide, 3-Pyridinecarboxamide
      Product Information
      CAS number98-92-0
      EC number202-713-4
      GradePh Eur,BP,USP,JP,FCC
      Hill FormulaC₆H₆N₂O
      Molar Mass122.13 g/mol
      HS Code2936 29 00
      Quality LevelMQ500
      Physicochemical Information
      Boiling point150 - 160 °C (0.0007 hPa)
      Density1.40 g/cm3 (25 °C)
      Flash point150 °C
      Ignition temperature480 °C
      Melting Point130 °C (sublimed)
      pH value6.0 - 7.5 (50 g/l, H₂O, 20 °C)
      Bulk density360 kg/m3
      Solubility691 g/l
      Toxicological Information
      LD 50 oralLD50 Rat 3530 - 3540 mg/kg
      LD 50 dermalLD50 Rabbit > 2000 mg/kg
      Safety Information according to GHS
      Hazard Pictogram(s) Hazard Pictogram(s)
      Hazard Statement(s)H319: Causes serious eye irritation.
      Precautionary Statement(s)P264: Wash skin thoroughly after handling.
      P280: Wear eye protection/ face protection.
      P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
      P337 + P313: If eye irritation persists: Get medical advice/ attention.
      Signal WordWarning
      RTECSQS3675000
      Storage class10 - 13 Other liquids and solids
      WGKWGK 1 slightly hazardous to water
      Disposal3
      Relatively unreactive organic reagents should be collected in container A. If halogenated, they should be collected in container B. For solid residues use container C.
      Safety Information
      Categories of dangerirritant
      Storage and Shipping Information
      StorageStore at +15°C to +25°C.
      Specifications
      Assay (perchloric acid titration, calculated on dried substance)99.0 - 101.0 %
      Assay (HPLC, calc. on dried substance)98.5 - 101.0 %
      Identity (IR-spectrum) (Ph Eur)passes test
      Identity (IR-spectrum) (USP)passes test
      Identity (coloring 1)passes test
      Identity (coloring 2)passes test
      Identity (UV/VIS-Spectrum)passes test
      AppearanceWhite to almost white, crystalline powder
      Appearance of solution (50 g/l; water)Clear, colourless, not more intense in color than reference solution BY₇
      pH (50 g/l; water)6.0 - 7.5
      Melting range (lower value)≥ 128 °C
      Melting range (upper value)≤ 131 °C
      Absorption ratio (A 245 nm/A 262 nm)0.63 - 0.67
      Chloride (Cl)≤ 210 ppm
      Sulfate (SO₄)≤ 190 ppm
      Pb (Lead)≤ 2 ppm
      Residual solvents (ICH Q3C)excluded by production process
      Readily carbonisable substancepasses test
      Related substances (HPLC) (Major unspecified impurity)≤ 0.10 %
      Related substances (HPLC) (Sum of all impurities)≤ 0.2 %
      Sulfated ash (600 °C)
      ≤ 0.1 %
      Loss on drying (Vacuum; 18 h)
      ≤ 0.5 %
      Elemental impurity specifications have been set considering ICH Q3D (Guideline for Elemental impurities). Class 1-3 elements are not likely to be present above the ICH Q3D option 1 limit, unless specified and indicated (*).
      Corresponds to Ph Eur, BP, USP, FCC, JP.
      Sulfated ash (600 °C)
      ≤ 0.1 %
      Loss on drying (Vacuum; 18 h)
      ≤ 0.5 %
      Elemental impurity specifications have been set considering ICH Q3D (Guideline for Elemental impurities). Class 1-3 elements are not likely to be present above the ICH Q3D option 1 limit, unless specified and indicated (*).
      Corresponds to Ph Eur, BP, USP, FCC, JP.
      Global Trade Item Number
      Catalogue Number GTIN
      5002999020 04022536722382