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489530 NOR-3

A cell-permeable, non-thiol, nitric oxide (NO) donor that can spontaneously release NO in a rate controlled manner (half-life (t1/2) in PBS, pH 7.4 is 30 minutes at 37°cC) generating biologically inactive by-products.

NOR-3 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (±)-(E)-Ethyl-2-[(E)-hydroxyimino]-5-nitro-3-hexeneamide, FK 409

489530
  
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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      163180-49-2C₈H₁₃N₃O₄
      Description
      Overview

      This product has been discontinued.





      A cell-permeable, non-thiol, nitric oxide (NO) donor that can spontaneously release NO in a rate controlled manner (half-life (t½) in PBS, pH 7.4 is 30 minutes at 37°C) generating biologically inactive by-products. Spontaneously releases NO intra- and extracellularly and activates intracellular soluble guanylate cyclase, leading to an increase in cGMP level and subsequent vascular relaxation or inhibition of platelet aggregation. Note: 1 set = 10 x 1 mg.
      Catalogue Number489530
      Brand Family Calbiochem®
      Synonyms(±)-(E)-Ethyl-2-[(E)-hydroxyimino]-5-nitro-3-hexeneamide, FK 409
      References
      ReferencesPercival, M.D., et al. 1999. Biochemistry 38, 13574.
      Kita, Y., et al. 1994. Br. J. Pharmacol. 113, 385.
      Kita, Y., et al. 1994. Eur. J. Pharmacol. 257, 123.
      Shibata, S., et al. 1991. J. Cardiovasc. Pharmacol. 17, 508.
      Yamada, H., et al. 1991. Br. J. Pharmacol. 103, 1713.
      Hino, N., et al. 1989. J. Antibiot. 42, 1578.
      Product Information
      CAS number163180-49-2
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₈H₁₃N₃O₄
      Chemical formulaC₈H₁₃N₃O₄
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary TargetNon-thiol, nitric oxide (NO) donor
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/37/38

      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      489530 0

      Documentation

      NOR-3 Certificates of Analysis

      TitleLot Number
      489530

      References

      Reference overview
      Percival, M.D., et al. 1999. Biochemistry 38, 13574.
      Kita, Y., et al. 1994. Br. J. Pharmacol. 113, 385.
      Kita, Y., et al. 1994. Eur. J. Pharmacol. 257, 123.
      Shibata, S., et al. 1991. J. Cardiovasc. Pharmacol. 17, 508.
      Yamada, H., et al. 1991. Br. J. Pharmacol. 103, 1713.
      Hino, N., et al. 1989. J. Antibiot. 42, 1578.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-August-2008 RFH
      Synonyms(±)-(E)-Ethyl-2-[(E)-hydroxyimino]-5-nitro-3-hexeneamide, FK 409
      DescriptionA cell-permeable nitric oxide (NO) donor that can release NO spontaneously in a rate controlled manner (t½ = 40 min) generating biologically inactive by-products. Spontaneously releases NO intra- and extracellularly and activates intracellular soluble guanylate cyclase, leading to an increase in the cGMP level and subsequent vascular relaxation or inhibition of platelet aggregation.
      FormWhite solid
      CAS number163180-49-2
      Chemical formulaC₈H₁₃N₃O₄
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (10 mg/ml). Further dilute with buffer just prior to use.
      Storage Protect from light
      -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Toxicity Irritant
      ReferencesPercival, M.D., et al. 1999. Biochemistry 38, 13574.
      Kita, Y., et al. 1994. Br. J. Pharmacol. 113, 385.
      Kita, Y., et al. 1994. Eur. J. Pharmacol. 257, 123.
      Shibata, S., et al. 1991. J. Cardiovasc. Pharmacol. 17, 508.
      Yamada, H., et al. 1991. Br. J. Pharmacol. 103, 1713.
      Hino, N., et al. 1989. J. Antibiot. 42, 1578.