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311203 NG,NG-Dimethyl-L-arginine, Dihydrochloride - CAS 220805-22-1 - Calbiochem

A cell-permeable, reversible inhibitor of nitric oxide synthase in vitro (IC₅₀ = 2-3 µM) and in vivo.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: ADMA, 2HCl

Primary Target: NOS in vitro
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311203
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
220805-22-1C₈H₁₈N₄O₂ . 2HCl

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311203-25MG
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      		 Plastic ampoule 25 mg
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      Description
      OverviewA cell-permeable, reversible inhibitor of nitric oxide synthase in vitro (IC50 = 2-3 µM) and in vivo. Causes dose-dependent vasoconstriction and bradycardic effects.
      Catalogue Number311203
      Brand Family Calbiochem®
      SynonymsADMA, 2HCl
      References
      ReferencesCloss, E.I., et al. 1997. Nitric Oxide 1, 65.
      Faraci, F.M., et al. 1995. Am. J. Physiol. 269, H1522.
      Gardiner, S.M., et al. 1993. Br. J. Pharmacol. 110, 1457.
      Kotani, K., et al. 1992. J. Neurochem. 58, 1127.
      Vallance, P., et al. 1992. Lancet 339, 572.
      Product Information
      CAS number220805-22-1
      ATP CompetitiveN
      FormWhite amorphous solid
      Hill FormulaC₈H₁₈N₄O₂ . 2HCl
      Chemical formulaC₈H₁₈N₄O₂ . 2HCl
      Hygroscopic Hygroscopic
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetNOS in vitro
      Primary Target IC<sub>50</sub>2-3 µM inhibiting nitric oxide synthase in vitro
      Purity≥98% by TLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      311203-25MG 04055977216851

      Documentation

      NG,NG-Dimethyl-L-arginine, Dihydrochloride - CAS 220805-22-1 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      NG,NG-Dimethyl-L-arginine, Dihydrochloride - CAS 220805-22-1 - Calbiochem Certificates of Analysis

      TitleLot Number
      311203

      References

      Reference overview
      Closs, E.I., et al. 1997. Nitric Oxide 1, 65.
      Faraci, F.M., et al. 1995. Am. J. Physiol. 269, H1522.
      Gardiner, S.M., et al. 1993. Br. J. Pharmacol. 110, 1457.
      Kotani, K., et al. 1992. J. Neurochem. 58, 1127.
      Vallance, P., et al. 1992. Lancet 339, 572.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-June-2008 RFH
      SynonymsADMA, 2HCl
      DescriptionEndogenous reversible inhibitor of nitric oxide synthesis in vitro and in vivo. Causes dose-dependent vasoconstriction and bradycardic effects.
      FormWhite amorphous solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number220805-22-1
      Chemical formulaC₈H₁₈N₄O₂ . 2HCl
      Structure formulaStructure formula
      Purity≥98% by TLC
      SolubilityH₂O (50 mg/ml)
      Storage -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
      Toxicity Standard Handling
      ReferencesCloss, E.I., et al. 1997. Nitric Oxide 1, 65.
      Faraci, F.M., et al. 1995. Am. J. Physiol. 269, H1522.
      Gardiner, S.M., et al. 1993. Br. J. Pharmacol. 110, 1457.
      Kotani, K., et al. 1992. J. Neurochem. 58, 1127.
      Vallance, P., et al. 1992. Lancet 339, 572.