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Cell Signaling Kits & MAPmates™
Choose fixed kits that allow you to explore entire pathways or processes. Or design your own kits by choosing single plex MAPmates™, following the provided guidelines.
The following MAPmates™ should not be plexed together:
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48-602MAG
Buffer Detection Kit for Magnetic Beads
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481408
Sigma-AldrichNF-κB Activation Inhibitor II, JSH-23 - CAS 749886-87-1 - Calbiochem
NF-kB Activation Inhibitor II, JSH-23, CAS 749886-87-1, is a cell-permeable, selective inhibitor of nuclear translocation of NF-kB p65 and its transcription activity (IC50 = 7.1 µM).
More>>NF-kB Activation Inhibitor II, JSH-23, CAS 749886-87-1, is a cell-permeable, selective inhibitor of nuclear translocation of NF-kB p65 and its transcription activity (IC50 = 7.1 µM). Less<<
MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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Description
Overview
A cell-permeable diamino compound that selectively blocks nuclear translocation of NF-κB p65 and its transcription activity (IC50 = 7.1 µM in a NF-κB reporter assay using RAW 264.7) without affecting IκB degradation. Shown to suppress DNA-binding of NF-κB and downregulate LPS-induced gene expression and apoptotic chromatin condensation.
NF-kB Activation Inhibitor II, JSH-23, CAS 749886-87-1, is a cell-permeable, selective inhibitor of nuclear translocation of NF-kB p65 and its transcription activity (IC50 = 7.1 µM).
Biological Information
Primary Target
Blocks nuclear translocation of NF-κB p65 and its transcription activity
Primary Target IC<sub>50</sub>
7.1 µM in a NF-κB reporter assay using RAW 264.7
Purity
≥95% by HPLC
Physicochemical Information
Cell permeable
Y
Storage and Shipping Information
Ship Code
Shipped with Blue Ice or with Dry Ice
Toxicity
Standard Handling
Storage
-20°C
Protect from Light
Protect from light
Do not freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas
Packaged under inert gas
Global Trade Item Number
Catalogue Number
GTIN
481408-5MG
07790788050672
Documentation
NF-κB Activation Inhibitor II, JSH-23 - CAS 749886-87-1 - Calbiochem SDS
NF-κB Activation Inhibitor II, JSH-23 - CAS 749886-87-1 - Calbiochem Certificates of Analysis
Title
Lot Number
481408
References
Reference overview
Shin, H.M., et al. 2004. FEBS Lett.571, 50.
Data Sheet
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
13-April-2011 RFH
Synonyms
4-Methyl-N¹-(3-phenylpropyl)benzene-1,2-diamine
Description
A cell-permeable, selective blocker of the nuclear translocation of NF-κB p65 that does not affect IκB degradation (IC50 = 7.1 µM in LPS-stimulated macrophages RAW 264.7 stably transfected with pNF-κB-SEAP-NPT). Shown to suppress DNA-binding of NF-κB and downregulate LPS-inducible expression of TNF-α, IL-1β, IL-6, iNOS, and COX-2. Also prevents LPS-induced apoptotic chromatin condensation.
Form
Off-white solid
Intert gas (Yes/No)
Packaged under inert gas
CAS number
749886-87-1
Chemical formula
C₁₆H₂₀N₂
Structure formula
Purity
≥95% by HPLC
Solubility
DMSO (10 mg/ml)
Storage
Protect from light -20°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
