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480025 NEMO-Binding Domain Binding Peptide, Cell-Permeable - Calbiochem

NEMO-Binding Domain Binding Peptide, Cell-Permeable, is an Antennapedia-NBD (wild type) fusion peptide that blocks the interaction of NEMO with the IKK (IκB)-kinase complex.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: DRQIKIWFQNRRMKWKKTALDWSWLQTE, NBD-Binding Peptide, Cell Permeable

Primary Target: cytokine-induced NF-κB activation and NF-κB-dependent gene expression
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      Overview

      Key Spec Table

      Empirical Formula
      C₁₇₀H₂₅₉N₄₉O₄₂S
      Description
      Overview

      This product has been discontinued.



      A cell-permeable Antennapedia-NBD (wild type) fusion peptide that exhibits anti-inflammatory properties. Acts by inhibiting cytokine-induced NF-κB activation and NF-κB-dependent gene expression. Suggested to block the interaction of NEMO with the IKK (IκB)-kinase complex and thereby prevents NF-κB activation. Does not affect the TNF-α-induced phosphorylation of c-Jun and DNA binding of the transcription factor Oct-1.
      Catalogue Number480025
      Brand Family Calbiochem®
      SynonymsDRQIKIWFQNRRMKWKKTALDWSWLQTE, NBD-Binding Peptide, Cell Permeable
      References
      ReferencesJimi, E., et al. 2004. Nat. Med., 10, 617.
      Siegmund, D., et al. 2001. J. Biol. Chem. 276, 43708.
      May, M.J., et al. 2000. Science 289, 1550.
      Li, Q., et al. 1999. Science 284, 321.
      Product Information
      ATP CompetitiveN
      FormWhite lyophilized solid
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₁₇₀H₂₅₉N₄₉O₄₂S
      Chemical formulaC₁₇₀H₂₅₉N₄₉O₄₂S
      Hygroscopic Hygroscopic
      ReversibleN
      Quality LevelMQ100
      Applications
      ApplicationNEMO-Binding Domain Binding Peptide, Cell-Permeable, is an Antennapedia-NBD (wild type) fusion peptide that blocks the interaction of NEMO with the IKK (IκB)-kinase complex.
      Biological Information
      Primary Targetcytokine-induced NF-κB activation and NF-κB-dependent gene expression
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Peptide SequenceH-Asp-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Thr-Ala-Leu-Asp-Trp-Ser-Trp-Leu-Gln-Thr-Glu-OH
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      480025 0