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399275 Nω-Hydroxy-nor-L-arginine, Diacetate Salt - CAS 189302-40-7 - Calbiochem

Nω-Hydroxy-nor-L-arginine, Diacetate Salt, CAS 189302-40-7, is a potent, selective, competitive, and high affinity inhibitor of arginase (IC50 = 2 µM for rat liver and 50 µM for mouse macrophages).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: nor-NOHA, 2CH₃CO₂H, L-2-Amino-(4-(2ʹ-hydroxyguanidino)butyric Acid, 2CH₃CO₂H

Primary Target: arginase from rat liver
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399275
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
189302-40-7C₅H₁₂N₄O₃ · 2CH₃CO₂H

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399275-1MG
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      399275-5MG
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          Description
          OverviewA potent, selective, competitive, and high affinity inhibitor of arginase. Shown to inhibit arginase from rat liver (IC50 = 2 µM) and mouse macrophages (IC50 = 50 µM). Shown to specifically interact with the manganese-cluster of the enzyme active site. Does not function as a substrate or as an inhibitor for NOS. Hence, nor-NOHA may be a useful tool to study the interplays between arginase and NOS.
          Catalogue Number399275
          Brand Family Calbiochem®
          Synonymsnor-NOHA, 2CH₃CO₂H, L-2-Amino-(4-(2ʹ-hydroxyguanidino)butyric Acid, 2CH₃CO₂H
          References
          ReferencesGobert, A.P., et al. 2000. Infect. Immun. 68, 4653.
          Meurs, H., et al. 2000. Br. J. Pharmacol. 130, 1793.
          Moali, C., et al. 2000. Biochemistry 39, 8208.
          Tenu, J.P. et al. 1999. Nitric Oxide 3, 427.
          Moali, C., et al. 1998. Biochemistry 37, 10453.
          Custot, J., et al. 1997. J. Am. Chem. Soc. 119, 4086.
          Product Information
          CAS number189302-40-7
          FormOff-white solid
          Hill FormulaC₅H₁₂N₄O₃ · 2CH₃CO₂H
          Chemical formulaC₅H₁₂N₄O₃ · 2CH₃CO₂H
          Hygroscopic Hygroscopic
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          ApplicationNω-Hydroxy-nor-L-arginine, Diacetate Salt, CAS 189302-40-7, is a potent, selective, competitive, and high affinity inhibitor of arginase (IC50 = 2 µM for rat liver and 50 µM for mouse macrophages).
          Biological Information
          Primary Targetarginase from rat liver
          Primary Target IC<sub>50</sub>2 µM
          Secondary targetmouse macrophages (IC₅₀ = 50 µM)
          Purity≥97% by TLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          Catalogue Number GTIN
          399275-1MG 04055977212563
          399275-5MG 07790788049881

          Documentation

          Nω-Hydroxy-nor-L-arginine, Diacetate Salt - CAS 189302-40-7 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          Nω-Hydroxy-nor-L-arginine, Diacetate Salt - CAS 189302-40-7 - Calbiochem Certificates of Analysis

          TitleLot Number
          399275

          References

          Reference overview
          Gobert, A.P., et al. 2000. Infect. Immun. 68, 4653.
          Meurs, H., et al. 2000. Br. J. Pharmacol. 130, 1793.
          Moali, C., et al. 2000. Biochemistry 39, 8208.
          Tenu, J.P. et al. 1999. Nitric Oxide 3, 427.
          Moali, C., et al. 1998. Biochemistry 37, 10453.
          Custot, J., et al. 1997. J. Am. Chem. Soc. 119, 4086.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision16-October-2007 JSW
          Synonymsnor-NOHA, 2CH₃CO₂H, L-2-Amino-(4-(2ʹ-hydroxyguanidino)butyric Acid, 2CH₃CO₂H
          DescriptionA potent, selective, competitive, and high affinity inhibitor of arginase. Shown to inhibit arginase from rat liver (IC50 = 2 µM) and mouse macrophages (IC50 = 50 µM). Specifically interacts with the manganese-cluster of the enzyme active site. Does not act as a substrate or as an inhibitor of NOS. Hence, it may serve as a useful tool to study the interplays between arginase and NOS.
          FormOff-white solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number189302-40-7
          Chemical formulaC₅H₁₂N₄O₃ · 2CH₃CO₂H
          Structure formulaStructure formula
          Purity≥97% by TLC
          SolubilityH₂O (50 mg/ml)
          Storage -20°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesGobert, A.P., et al. 2000. Infect. Immun. 68, 4653.
          Meurs, H., et al. 2000. Br. J. Pharmacol. 130, 1793.
          Moali, C., et al. 2000. Biochemistry 39, 8208.
          Tenu, J.P. et al. 1999. Nitric Oxide 3, 427.
          Moali, C., et al. 1998. Biochemistry 37, 10453.
          Custot, J., et al. 1997. J. Am. Chem. Soc. 119, 4086.