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475820 Mitomycin C, Streptomyces caespitosus, Carrier-Free - CAS 50-07-7 - Calbiochem

Antibiotic and carcinostatic agent. Inhibits DNA synthesis by cross-linking DNA at guanine and adenine residues; disrupts base pairing. Induces apoptosis in gastric cancer cells.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Mitocin C, MMC

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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      50-07-7C₁₅H₁₈N₄O₅
      Description
      OverviewAntibiotic and carcinostatic agent. Inhibits DNA synthesis by cross-linking DNA at guanine and adenine residues; disrupts base pairing. Induces apoptosis in gastric cancer cells. Blocks the cell cycle at the G2 phase. Potency: ≥970 µg/mg.
      Catalogue Number475820
      Brand Family Calbiochem®
      SynonymsMitocin C, MMC
      References
      ReferencesKryt, F.A., et al. 1996. Blood 89, 938.
      Schwartz, G.K., et al. 1995. J. Natl. Cancer Inst. 87, 1394.
      Folnan, R.S., 1993. Oncology 50, 24.
      Tomasz, M., et al. 1987. Science 235, 1204.
      Product Information
      CAS number50-07-7
      FormPurple solid
      Hill FormulaC₁₅H₁₈N₄O₅
      Chemical formulaC₁₅H₁₈N₄O₅
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Biological activityPotency: ≥ 970 μg/mg mitomycin C
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSCN0700000
      Safety Information
      R PhraseR: 28

      Very toxic if swallowed.
      S PhraseS: 36/37-45-28

      Wear suitable protective clothing and gloves.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Highly Toxic & Carcinogenic / Teratogenic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      475820 0

      Documentation

      Mitomycin C, Streptomyces caespitosus, Carrier-Free - CAS 50-07-7 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Mitomycin C, Streptomyces caespitosus, Carrier-Free - CAS 50-07-7 - Calbiochem Certificates of Analysis

      TitleLot Number
      475820

      References

      Reference overview
      Kryt, F.A., et al. 1996. Blood 89, 938.
      Schwartz, G.K., et al. 1995. J. Natl. Cancer Inst. 87, 1394.
      Folnan, R.S., 1993. Oncology 50, 24.
      Tomasz, M., et al. 1987. Science 235, 1204.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision30-April-2010 JSW
      SynonymsMitocin C, MMC
      DescriptionAntibiotic and carcinostatic agent. Inhibits DNA synthesis by cross-linking DNA at guanine and adenine residues; disrupts base pairing. Induces apoptosis in gastic cancer cells. Blocks the cell cycle at the G2 phase.
      FormPurple solid
      CAS number50-07-7
      RTECSCN0700000
      Chemical formulaC₁₅H₁₈N₄O₅
      Structure formulaStructure formula
      Purity≥95% by HPLC
      Biological activityPotency: ≥ 970 μg/mg mitomycin C
      SolubilityH₂O (<1 mg/ml) or Methanol (5 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Highly Toxic & Carcinogenic / Teratogenic
      Merck USA index14, 6215
      ReferencesKryt, F.A., et al. 1996. Blood 89, 938.
      Schwartz, G.K., et al. 1995. J. Natl. Cancer Inst. 87, 1394.
      Folnan, R.S., 1993. Oncology 50, 24.
      Tomasz, M., et al. 1987. Science 235, 1204.