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FCMAB408PE Milli-Mark® Anti-GABA A Receptor β2/3-PE Antibody, clone 62-3G1

Milli-Mark Anti-GABA A Receptor β2/3-PE Antibody, clone 62-3G1 detects level of Milli-Mark GABA A Receptor β2/3-PE & has been published & validated for use in Flow Cytometry.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Neurotransmitters & Receptors Gene Symbol: GABRA1, GABA, EJM UniProt Number: P14867
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FCMAB408PE
100 tests  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      RFCMPhycoerythrinMonoclonal Antibody
      Description
      Catalogue NumberFCMAB408PE
      Trade Name
      • Milli-Mark
      DescriptionMilli-Mark® Anti-GABA A Receptor β2/3-PE Antibody, clone 62-3G1
      Alternate Names
      • Gamma-amino butyric acid receptor subunit alpha-1
      • GABA(A) receptor subunit alpha-1
      • gamma-aminobutyric acid (GABA) A receptor, alpha 1
      Background InformationThe neurotransmitter GABA (gamma-aminobutyric acid) binds to specific transmembrane receptors in the plasma membrane of both pre- and postsynaptic neurons. Three general classes of GABA receptors are known: GABAA and GABAC (ionotropic) receptors and GABAB (metabotropic) receptors. The GABAA (gamma-Aminobutyric Acid type A) receptor is a multiprotein complex that acts as a ligand-gated chloride channel. These receptors are hetero-oligomers, for which 6 subunits are currently known (a, b, g, d, e and r). There are at least 3 different isoforms of the beta subunit, and receptor subunit expression varies during development. Additionally, GABAA receptors are important in regulating the reinforcing properties of alcohol, and expression of the alpha1 and beta 2/3 subunits increase upon chronic exposure to alcohol, and may be potential therapeutic targets for alcohol dependency. The beta 2 subunit is required for receptor assembly and surface expression, while mice with an inactivated beta3 subunit exhibit epilepsy and cleft palate.
      References
      Product Information
      FormatPhycoerythrin
      Control
      • B35 cells
      PresentationPurified mouse monoclonal IgG1 conjugated to PE in PBS with 0.1% sodium azide and 15 mg/mL BSA.
      Quality LevelMQ100
      Applications
      ApplicationMilli-Mark Anti-GABA A Receptor β2/3-PE Antibody, clone 62-3G1 detects level of Milli-Mark GABA A Receptor β2/3-PE & has been published & validated for use in Flow Cytometry.
      Key Applications
      • Flow Cytometry
      Biological Information
      ImmunogenAffinity-purified GABAA receptor isolated from bovine brain.
      Clone62-3G1
      HostMouse
      IsotypeIgG1
      Species Reactivity
      • Rat
      Species Reactivity NoteDemonstrated to react with Rat. Predicted to react with Bovine based on immunogen design.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • GABRA1
      • GABA
      • EJM
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight55 and 57 kDa calculated. Specific for the GABAA Receptor β2 subunit, MW ~55 kDa and β3 subunit, MW ~57 kDa.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by flow cytometry using B35 cells
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain refrigerated at 2-8°C protected from light in undiluted aliquots for up to 6 months from date of receipt.
      Packaging Information
      Material Size100 tests
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      FCMAB408PE 04053252820748

      Documentation

      Milli-Mark® Anti-GABA A Receptor β2/3-PE Antibody, clone 62-3G1 SDS

      Title

      Safety Data Sheet (SDS) 

      Milli-Mark® Anti-GABA A Receptor β2/3-PE Antibody, clone 62-3G1 Certificates of Analysis

      TitleLot Number
      Milli-Mark#174; Anti-GABA A Receptor 2/3-PE, clone 62-3G1 - Q2075188 Q2075188
      Milli-Mark® Anti-GABA A Receptor β2/3-PE, clone 62-3G1 - 3140434 3140434
      Milli-Mark® Anti-GABA A Receptor β2/3-PE, clone 62-3G1 -2527490 2527490
      Milli-Mark® Anti-GABA A Receptor β2/3-PE, clone 62-3G1 -2719445 2719445
      Milli-Mark® Anti-GABA A Receptor β2/3-PE, clone 62-3G1 Conjugate 2884265

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies