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GF048 Macrophage Inflammatory Protein-1α Protein, Recombinant rat

The rat macrophage inflammatory protein-1alpha ( or MIP-1alpha protein) is an 7.8 kDa protein containing 69 amino acid residues.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Key Applications: Cell Culture UniProt Number: P10147, P50229
GF048
20 µg  
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      Overview

      Key Spec Table

      Key ApplicationsSpeciesSourcePurity
      CULTRat E. coliGreater than 95% by SDS-PAGE and HPLC analysis.
      Description
      Catalogue NumberGF048
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionMacrophage Inflammatory Protein-1α Protein, Recombinant rat
      OverviewRat macrophage inflammatory protein-1alpha (MIP-1alpha) is an 7.8 kDa protein containing 69 amino acid residues. It plays an important role in the inflammatory response of blood monocytes and tissue macrophages.
      Alternate Names
      • MIP-1alpha
      Product Information
      PresentationLyophilized powder with no additives.
      Quality LevelMQ100
      Applications
      ApplicationThe rat macrophage inflammatory protein-1alpha ( or MIP-1alpha protein) is an 7.8 kDa protein containing 69 amino acid residues.
      Key Applications
      • Cell Culture
      Biological Information
      PurityGreater than 95% by SDS-PAGE and HPLC analysis.
      SourceE. coli
      Specific ActivityGF048 produces chemotaxis over a wide concentration range in an assay using rat peritoneal macrophages. Significant chemotaxis was achieved using a concentration of 50-100 ng/mL.
      Entrez Gene SummaryMacrophage inflammatory protein-1 is a so-called monokine that is involved in the acute inflammatory state in the recruitment and activation of polymorphonuclear leukocytes (Wolpe et al., 1988 [PubMed 3279154]). Sherry et al. (1988) [PubMed 3058856] demonstrated 2 protein components of MIP1, called by them alpha and beta.[supplied by OMIM]
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P10147 # Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV).
      SIZE: 92 amino acids; 10085 Da
      SUBUNIT: Self-associates. Also heterodimer of MIP-1-alpha(4-69) and MIP-1-beta(3-69).
      SUBCELLULAR LOCATION: Secreted.
      PTM: N-terminal processed form LD78-alpha(4-69) is produced by proteolytic cleavage after secretion from HTLV1-transformed T- cells.
      SIMILARITY: SwissProt: P10147 ## Belongs to the intercrine beta (chemokine CC) family.
      Stem Cell Type
      • Hematopoietic Stem Cells
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsThe lyophilized powder, though stable at room temperature, is best stored at -20°C. Reconstitute in water to a concentration of 0.1-1.0 mg/mL. Further dilutions can be made into other aqueous buffers and stored at 2-8 ºC for 1 week or -20 ºC for future use. Reconstituted rat MIP-1alpha should be stored in undiluted aliquots at -20°C for up to 6 months.
      Packaging Information
      Material Size20 µg
      Global Trade Item Number
      Catalogue Number GTIN
      GF048 04053252271328