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420129 JNK Inhibitor V - CAS 345987-15-7 - Calbiochem

The JNK Inhibitor V, also referenced under CAS 345987-15-7, controls the biological activity of JNK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: SAPK Inhibitor V, 1,3-Benzothiazol-2-yl-(2-((2-(3-pyridinyl)ethyl)amino)-4-pyrimidinyl)acetonitrile, AS601245

Primary Target: hJNK 1, hJNK 2, hJNK 3
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420129
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
345987-15-7C₂₀H₁₆N₆S

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      Description
      OverviewA cell-permeable pyrimidinyl compound that displays anti-inflammatory properties. Acts as a potent, reversible, and ATP-competitive inhibitor of c-Jun N-terminal kinase (JNK, IC50 = 150, 220, and 70 nM for hJNK1, hJNK2, and hJNK3, respectively) with a 10- to 100-fold greater selectivity over a panel of 25 other commonly studied kinases (IC50 typically in the range of 1-10 µM or no effect at 10 µM). Its in vivo efficacy has been demonstrated in gerbils, mice, and rats via oral, i.v., or i.p. administration.
      Catalogue Number420129
      Brand Family Calbiochem®
      SynonymsSAPK Inhibitor V, 1,3-Benzothiazol-2-yl-(2-((2-(3-pyridinyl)ethyl)amino)-4-pyrimidinyl)acetonitrile, AS601245
      References
      ReferencesGaillard, P., et al. 2005. J. Med. Chem. 48, 4596.
      Carboni, S., et al. 2005. J. Neurochem. 92, 1054.
      Ferrandi, C., et al. 2004. Br. J. Pharmacol. 142, 953.
      Carboni, S., et al. 2004. J. Pharm. Exp. Ther. 310, 25.
      Product Information
      CAS number345987-15-7
      ATP CompetitiveY
      FormYellow solid
      Hill FormulaC₂₀H₁₆N₆S
      Chemical formulaC₂₀H₁₆N₆S
      Hygroscopic Hygroscopic
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Application CommentsSoluble in DMSO, aliquot & store at -20*C; stable for 3 months
      Biological Information
      Primary TargethJNK 1, hJNK 2, hJNK 3
      Primary Target IC<sub>50</sub>150, 220, and 70 nM for hJNK1, hJNK2, and hJNK3, respectively
      Purity≥95% by HPLC (sum of two isomers)
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      420129-5MG 04055977188073

      Documentation

      JNK Inhibitor V - CAS 345987-15-7 - Calbiochem Certificates of Analysis

      TitleLot Number
      420129

      References

      Reference overview
      Gaillard, P., et al. 2005. J. Med. Chem. 48, 4596.
      Carboni, S., et al. 2005. J. Neurochem. 92, 1054.
      Ferrandi, C., et al. 2004. Br. J. Pharmacol. 142, 953.
      Carboni, S., et al. 2004. J. Pharm. Exp. Ther. 310, 25.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision04-January-2010 RFH
      SynonymsSAPK Inhibitor V, 1,3-Benzothiazol-2-yl-(2-((2-(3-pyridinyl)ethyl)amino)-4-pyrimidinyl)acetonitrile, AS601245
      DescriptionA cell-permeable pyrimidinyl compound that displays anti-inflammatory properties. Acts as a potent, reversible, and ATP-competitive inhibitor of c-Jun N-terminal kinase (JNK, IC50 = 150, 220, and 70 nM for hJNK1, hJNK2, and hJNK3, respectively) with a 10- to 100-fold greater selectivity over a panel of 25 other commonly studied kinases (IC50 typically in the range of 1-10 µM or no effect at 10 µM). Its in vivo efficacy has been demonstrated in gerbils, mice, and rats via oral, i.v., or i.p. administration.
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number345987-15-7
      Chemical formulaC₂₀H₁₆N₆S
      Structure formulaStructure formula
      Purity≥95% by HPLC (sum of two isomers)
      SolubilityDMSO (10 mg/ml)
      CommentsSoluble in DMSO, aliquot & store at -20*C; stable for 3 months
      Storage Protect from light
      -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Harmful
      ReferencesGaillard, P., et al. 2005. J. Med. Chem. 48, 4596.
      Carboni, S., et al. 2005. J. Neurochem. 92, 1054.
      Ferrandi, C., et al. 2004. Br. J. Pharmacol. 142, 953.
      Carboni, S., et al. 2004. J. Pharm. Exp. Ther. 310, 25.