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407652 Interleukin-6, Human, Recombinant, E. coli

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407652
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407652-10UG
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      Description
      OverviewRecombinant, human, interleukin-6 expressed in E. coli. A prototypic pleiotrophic, pro-inflammatory cytokine that stimulates the production of acute phase proteins by hepatocytes. Also known to induce skeletal muscle protein breakdown. Induces growth and differentiation of B cells, T cells, and hepatocytes. Stimulates growth and inhibits constitutive, protein synthesis-independent apoptosis of murine B cell hybridoma 7TD1. IL-6 is produced by macrophages, endothelial cells, and activated T helper cells. Also considered as a potential marker of adipocyte differentiation. Human IL-6 is active on murine cells.
      Catalogue Number407652
      Brand Family Calbiochem®
      SynonymsrhIL-6
      References
      ReferencesVicennati, V., et al. 2002. Int. J. Obes. Relat. Metab. Disord. 26, 9.
      Vallieres, L., and Rivest, S. 1999. Endocrinology 140, 3890.
      Goodman, M.N. 1994. Proc. Soc. Exp. Biol. Med. 205, 182.
      Liu, J., et al. 1994. Cell Immunol. 155, 229.
      Van Snick, J. 1990. Annu. Rev. Immunol. 8, 253.
      Product Information
      FormLyophilized
      FormulationCarrier free.
      Quality LevelMQ100
      Biological Information
      Biological activity8-20 pg/ml as measured in a cell proliferation assay with a factor-dependent murine plasmacytoma cell line, B9.
      Purity≥95% by SDS-PAGE
      Physicochemical Information
      ContaminantsEndotoxin: ≤1.0 EU/µg IL-6
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage ≤ -70°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 3 months at -70°C. Avoid freeze/thaw cycles of solutions.
      Global Trade Item Number
      Catalogue Number GTIN
      407652-10UG 04055977211405