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203293 InSolution™ Bisindolylmaleimide I - CAS 133052-90-1 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-[1-(3-Dimethylaminopropyl)-1H-indol-3-yl]-3-(1H-indol-3-yl)-maleimide, Gö 6850

Primary Target: PKC
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203293
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
133052-90-1C₂₅H₂₄N₄O₂

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203293-1ML
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      Description
      Catalogue Number203293
      Brand Family Calbiochem®
      Synonyms2-[1-(3-Dimethylaminopropyl)-1H-indol-3-yl]-3-(1H-indol-3-yl)-maleimide, Gö 6850
      References
      ReferencesKu, W.-C., et al. 1997. Biochem. Biophys. Res. Commun. 241, 730.
      Gekeler, V., et al. 1996. Br. J. Cancer 74, 897.
      Kiss, Z., et al. 1995. Biochim. Biophys. Acta 1265, 93.
      Muid, R.E., et al. 1991. FEBS Lett. 293, 160.
      Toullec, D., et al. 1991. J. Biol. Chem. 266, 15771.
      Product Information
      CAS number133052-90-1
      ATP CompetitiveY
      FormLiquid
      FormulationA 1 mg/ml solution of Bisindolylmaleimide I (Cat. No. 203290) in anhydrous DMSO.
      Hill FormulaC₂₅H₂₄N₄O₂
      Chemical formulaC₂₅H₂₄N₄O₂
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPKC
      Primary Target K<sub>i</sub>10 nM against PKC
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/38

      Irritating to eyes and skin.
      S PhraseS: 26

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Irritant
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      203293-1ML 04055977221183

      Documentation

      InSolution™ Bisindolylmaleimide I - CAS 133052-90-1 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      InSolution™ Bisindolylmaleimide I - CAS 133052-90-1 - Calbiochem Certificates of Analysis

      TitleLot Number
      203293

      References

      Reference overview
      Ku, W.-C., et al. 1997. Biochem. Biophys. Res. Commun. 241, 730.
      Gekeler, V., et al. 1996. Br. J. Cancer 74, 897.
      Kiss, Z., et al. 1995. Biochim. Biophys. Acta 1265, 93.
      Muid, R.E., et al. 1991. FEBS Lett. 293, 160.
      Toullec, D., et al. 1991. J. Biol. Chem. 266, 15771.

      Citations

      Title
    • Alexandra Thiel, Mira Heinonen, Johanna Rintahaka, Tuija Hallikainen, and Annabrita Hemmes, Dan A. Dixon, Caj Haglund, and Ari Ristimaki. (2006) EXPRESSION OF CYCLOOXYGENASE-2 IS REGULATED BY GSK-3 IN GASTRIC CANCER CELLS. Journal of Biological Chemistry in press,.
    • Xiaohua Jiang, et al. (2005) Hyperhomocystinemia impairs endothelial function and eNOS activity via PKC activation. Arteriosclerosis, Thrombosis, and Vascular Biology in press,.
    • Ademi E. Santiago-Walker, et al. (2005) Protein Kinase C δ Stimulates Apoptosis by Initiating G1 Phase Cell Cycle Progression and S Phase Arrest. Journal of Biological Chemistry 280, 32107-32114.
    • Wojciech Wojciechowski, et al. (2005) Enhanced Expression of CD20 in Human Tumor B Cells is Controlled Through ERK-Dependent Mechanisms. Journal of Immunology 174, 7859-7868.
      		•
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision20-May-2008 RFH
      Synonyms2-[1-(3-Dimethylaminopropyl)-1H-indol-3-yl]-3-(1H-indol-3-yl)-maleimide, Gö 6850
      DescriptionA highly selective cell-permeable protein kinase C (PKC) inhibitor (Ki = 10 nM) that is structurally similar to staurosporine. Acts as a competitive inhibitor for the ATP-binding site of PKC. Shows high selectivity for PKCα, βI, βII, γ, δ, and ε isozymes. May inhibit protein kinase A at a much higher concentration (Ki = 2 µM). Also inhibits telomerase A treated NPC-076 cells. A 1 mg/ml solution of Bisindolylmaleimide I (Cat. No. 203290) in anhydrous DMSO.
      FormLiquid
      FormulationA 1 mg/ml solution of Bisindolylmaleimide I (Cat. No. 203290) in anhydrous DMSO.
      Intert gas (Yes/No) Packaged under inert gas
      CAS number133052-90-1
      Chemical formulaC₂₅H₂₄N₄O₂
      Structure formulaStructure formula
      Purity≥95% by HPLC
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Toxicity Irritant
      ReferencesKu, W.-C., et al. 1997. Biochem. Biophys. Res. Commun. 241, 730.
      Gekeler, V., et al. 1996. Br. J. Cancer 74, 897.
      Kiss, Z., et al. 1995. Biochim. Biophys. Acta 1265, 93.
      Muid, R.E., et al. 1991. FEBS Lett. 293, 160.
      Toullec, D., et al. 1991. J. Biol. Chem. 266, 15771.
      Citation
    • Alexandra Thiel, Mira Heinonen, Johanna Rintahaka, Tuija Hallikainen, and Annabrita Hemmes, Dan A. Dixon, Caj Haglund, and Ari Ristimaki. (2006) EXPRESSION OF CYCLOOXYGENASE-2 IS REGULATED BY GSK-3 IN GASTRIC CANCER CELLS. Journal of Biological Chemistry in press,.
    • Xiaohua Jiang, et al. (2005) Hyperhomocystinemia impairs endothelial function and eNOS activity via PKC activation. Arteriosclerosis, Thrombosis, and Vascular Biology in press,.
    • Ademi E. Santiago-Walker, et al. (2005) Protein Kinase C δ Stimulates Apoptosis by Initiating G1 Phase Cell Cycle Progression and S Phase Arrest. Journal of Biological Chemistry 280, 32107-32114.
    • Wojciech Wojciechowski, et al. (2005) Enhanced Expression of CD20 in Human Tumor B Cells is Controlled Through ERK-Dependent Mechanisms. Journal of Immunology 174, 7859-7868.
      		•