Millipore Sigma Vibrant Logo

400087 HIF-2α Translation Inhibitor - CAS 882268-69-1 - Calbiochem

Overview

Key Spec Table

CAS #Empirical Formula
882268-69-1C₉H₉N₃O₄S₂

Pricing & Availability

Catalogue Number AvailabilityPackaging Qty/Pack Price Quantity
400087-10MG
Limited Availability
Limited Availability
In Stock 
Discontinued
Limited Quantities Available
Availability to be confirmed
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service

      Glass bottle 10 mg
      Price could not be retrieved
      Minimum Quantity is a multiple of
      Maximum Quantity is
      Upon Order Completion More Information
      You Saved ()
       
      Request Pricing
      Description
      OverviewA cell-permeable thienylhydrazone compound that suppresses the translation of cellular HIF-2α message by enhancing the binding of IRP1 (Iron-Regulatory Protein 1) to the IRE (Iron-Responsive Element) region at the 5' UTR of the HIF-2α mRNA, exhibiting otherwise no effects toward the transcription of HIF-2α mRNA or the stability of HIF-2α mRNA and protein. Shown to reduce cellular protein levels of HIF-2α and HIF-2α target genes, including Glut-1, IGFBP3, and VEGF, in 786-O cells (5 to 10 µM final concentration) that express only the 2α isoform of hypoxia-inducible factor.
      Catalogue Number400087
      Brand Family Calbiochem®
      SynonymsHypoxia-Inducible Factor-2α Translation Inhibitor, Methyl-3-(2-(cyano(methylsulfonyl)methylene)hydrazino)thiophene-2-carboxylate, HIF Inhibitor II
      References
      ReferencesZimmer, M., et al. 2008. Mol. Cell 32, 838.
      Product Information
      CAS number882268-69-1
      FormAmber solid
      Hill FormulaC₉H₉N₃O₄S₂
      Chemical formulaC₉H₉N₃O₄S₂
      Structure formula ImageStructure formula Image
      Quality LevelMQ200
      Biological Information
      Purity≥95% (sum of two isomers)
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      400087-10MG 04055977212341