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370665 Guanosine-3ʹ-5ʹ-cyclic Monophosphate, 8-(4-Chlorophenylthio)-, Triethylammonium Salt - Calbiochem

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370665
  
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      Overview

      Key Spec Table

      Empirical Formula
      C₁₆H₁₄ClN₅O₇PS · (CH₃CH₂)₃NH
      Description
      OverviewSelective membrane-permeable activator of protein kinase G that has a higher activation potential than cGMP. Does not significantly affect cGMP-regulated phosphodiesterases. Inhibits the thrombin-induced phosphorylation of human platelets mediated by myosin light chain kinase (MLCK) and protein kinase C (PKC). Note: 25 µmol = 14.73 mg.
      Catalogue Number370665
      Brand Family Calbiochem®
      Synonyms8-pCPT-cGMP, TEA
      References
      ReferencesAlioua, A., et al. 1998. J. Biol. Chem. 273, 32950.
      Draijer, R., et al. 1995. Circ. Res. 77, 895.
      Geiger, J., et al. 1992. Proc. Natl. Acad. Sci. USA 89, 1031.
      Wolfe, L., et al. 1989. J. Biol. Chem. 264, 7734.
      Product Information
      ATP CompetitiveN
      FormLyophilized
      Hill FormulaC₁₆H₁₄ClN₅O₇PS · (CH₃CH₂)₃NH
      Chemical formulaC₁₆H₁₄ClN₅O₇PS · (CH₃CH₂)₃NH
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetProtein kinase G
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Global Trade Item Number
      Catalogue Number GTIN
      370665 0