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345834 Genistein, Soybean - CAS 446-72-0 - Calbiochem

A cell-permeable, reversible, substrate competitive inhibitor of protein tyrosine kinases, including autophosphorylation of epidermal growth factor receptor kinase (IC₅₀ = 2.6 µM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 4ʹ,5,7-Trihydroxyisoflavone

Primary Target: EGFR kinase
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345834
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
446-72-0C₁₅H₁₀O₅

Pricing & Availability

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345834-20MG
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      345834-50MG
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          Description
          OverviewA cell-permeable, reversible, substrate competitive inhibitor of protein tyrosine kinases, including autophosphorylation of epidermal growth factor receptor kinase (IC50 = 2.6 µM). The inhibition is competitive with respect to ATP and non-competitive with respect to the phosphate acceptor. Has only a trivial effect on the activity of PKA and PKC (IC50 > 350 µM). Inhibits tumor cell proliferation and induces tumor cell differentiation. Produces cell cycle arrest and apoptosis in Jurkat T-leukemia cells. However, it prevents anti-CD3 monoclonal antibody-induced thymic apoptosis. Also inhibits topoisomerase II activity in vitro.
          Catalogue Number345834
          Brand Family Calbiochem®
          Synonyms4ʹ,5,7-Trihydroxyisoflavone
          References
          ReferencesConstantinou, A., and Huberman, E. 1995. Proc. Soc. Exp. Biol. Med. 208, 109.
          Wei, H., et al. 1995. Proc. Soc. Exp. Biol. Med. 208, 124.
          Wei, H., et al. 1995. Carcinogenesis 17, 73.
          Kobayashi, S., et al. 1994. J. Biol. Chem. 269, 9011.
          Migita, K., et al. 1994. J. Immunol. 153, 3457.
          Spinozzi, F., et al. 1994. Leuk. Res. 18, 431.
          Dhar, A., et al. 1990. Mol. Pharmacol. 37, 519.
          Hill, T.D., et al. 1990. Science 248, 1660.
          Dean, N.M., et al. 1989. Biochem. Biophys. Res. Commun. 165, 795.
          Akiyama, T., et al. 1987. J. Biol. Chem. 262, 5592.
          Product Information
          CAS number446-72-0
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₁₅H₁₀O₅
          Chemical formulaC₁₅H₁₀O₅
          ReversibleY
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary TargetEGFR kinase
          Primary Target IC<sub>50</sub>2.6 µM against autophosphorylation of epidermal growth factor receptor kinase
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSNR2392000
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          Catalogue Number GTIN
          345834-20MG 04055977214376
          345834-50MG 04055977214383

          Documentation

          Genistein, Soybean - CAS 446-72-0 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          Genistein, Soybean - CAS 446-72-0 - Calbiochem Certificates of Analysis

          TitleLot Number
          345834

          References

          Reference overview
          Constantinou, A., and Huberman, E. 1995. Proc. Soc. Exp. Biol. Med. 208, 109.
          Wei, H., et al. 1995. Proc. Soc. Exp. Biol. Med. 208, 124.
          Wei, H., et al. 1995. Carcinogenesis 17, 73.
          Kobayashi, S., et al. 1994. J. Biol. Chem. 269, 9011.
          Migita, K., et al. 1994. J. Immunol. 153, 3457.
          Spinozzi, F., et al. 1994. Leuk. Res. 18, 431.
          Dhar, A., et al. 1990. Mol. Pharmacol. 37, 519.
          Hill, T.D., et al. 1990. Science 248, 1660.
          Dean, N.M., et al. 1989. Biochem. Biophys. Res. Commun. 165, 795.
          Akiyama, T., et al. 1987. J. Biol. Chem. 262, 5592.

          Citations

          Title
        • Weijian Shao, Roy C. Orlando and Mouhamed S. Awayda. (2005) Bisphosphonates stimulate an endogenous nonselective cation channel in Xenopus oocytes: potential mechanism of action. American Journal of Physiology Cell Physiology 289, C248-C256.
          		•
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision16-April-2010 JSW
          Synonyms4ʹ,5,7-Trihydroxyisoflavone
          DescriptionA cell-permeable, reversible, substrate competitive inhibitor of protein tyrosine kinases, including autophosphorylation of epidermal growth factor receptor kinase (IC50 = 2.6 µM). The inhibition is competitive with respect to ATP and non-competitive with respect to the phosphate acceptor. Inhibits tumor cell proliferation and induces tumor cell differentiation. Inhibits exogenous substrate phosphorylation by EGFR kinase and pp60v-src with similar potencies (IC50 = 20-25 µM). Has only a trivial effect on PKC and PKA (IC50 >350 µM). Produces cell cycle arrest and apoptosis in Jurkat T-leukemia cells. Prevents anti-CD3 monoclonal antibody-induced thymic apoptosis. Also inhibits topoisomerase II activity in vitro. Blocks oxidative DNA damage in vitro.
          FormWhite solid
          CAS number446-72-0
          RTECSNR2392000
          Chemical formulaC₁₅H₁₀O₅
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (200 mg/ml)
          Storage Protect from light
          -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          Merck USA index14, 4391
          ReferencesConstantinou, A., and Huberman, E. 1995. Proc. Soc. Exp. Biol. Med. 208, 109.
          Wei, H., et al. 1995. Proc. Soc. Exp. Biol. Med. 208, 124.
          Wei, H., et al. 1995. Carcinogenesis 17, 73.
          Kobayashi, S., et al. 1994. J. Biol. Chem. 269, 9011.
          Migita, K., et al. 1994. J. Immunol. 153, 3457.
          Spinozzi, F., et al. 1994. Leuk. Res. 18, 431.
          Dhar, A., et al. 1990. Mol. Pharmacol. 37, 519.
          Hill, T.D., et al. 1990. Science 248, 1660.
          Dean, N.M., et al. 1989. Biochem. Biophys. Res. Commun. 165, 795.
          Akiyama, T., et al. 1987. J. Biol. Chem. 262, 5592.
          Citation
        • Weijian Shao, Roy C. Orlando and Mouhamed S. Awayda. (2005) Bisphosphonates stimulate an endogenous nonselective cation channel in Xenopus oocytes: potential mechanism of action. American Journal of Physiology Cell Physiology 289, C248-C256.
          		•