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344154 FPT Inhibitor III - Calbiochem

The FPT Inhibitor III controls the biological activity of FPT. This small molecule/inhibitor is primarily used for Cancer applications.

FPT Inhibitor III - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (E,E)-[2-Oxo-2-[[(3,7,11-trimethyl-2,6,10-dodecatrienyl)oxy]amino]ethyl]phosphonic Acid, (2,2-Dimethyl-1-oxopropoxy)methyl Ester, Na

Primary Target: FTase
344154
  
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      Overview

      Replacement Information

      Key Spec Table

      Empirical Formula
      C₂₃H₃₉NO₇P . Na
      Description
      Overview

      This product has been discontinued.





      A cell-permeable prodrug ester form of farnesyltransferase (FTase) inhibitor II (Cat. No. 344152). Also inhibits Ras processing in cells (~100 µM), thereby preventing Ras-mediated transformation. Inhibits C15 and C20 protein prenylation in NIH-3T3 cells.
      Catalogue Number344154
      Brand Family Calbiochem®
      Synonyms(E,E)-[2-Oxo-2-[[(3,7,11-trimethyl-2,6,10-dodecatrienyl)oxy]amino]ethyl]phosphonic Acid, (2,2-Dimethyl-1-oxopropoxy)methyl Ester, Na
      References
      ReferencesWang, D., et al. 1998. J. Biol. Chem. 273, 33027.
      Manne, V., et al. 1995. Drug Development Res. 34, 121.
      Product Information
      ATP CompetitiveN
      FormPale yellow solid
      Hill FormulaC₂₃H₃₉NO₇P . Na
      Chemical formulaC₂₃H₃₉NO₇P . Na
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary TargetFTase
      Primary Target IC<sub>50</sub>~100 µM inhibiting Ras processing in cells, thereby preventing Ras-mediated transformation
      Purity≥90% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      344154 0

      Documentation

      FPT Inhibitor III - Calbiochem Certificates of Analysis

      TitleLot Number
      344154

      References

      Reference overview
      Wang, D., et al. 1998. J. Biol. Chem. 273, 33027.
      Manne, V., et al. 1995. Drug Development Res. 34, 121.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision26-June-2008 RFH
      Synonyms(E,E)-[2-Oxo-2-[[(3,7,11-trimethyl-2,6,10-dodecatrienyl)oxy]amino]ethyl]phosphonic Acid, (2,2-Dimethyl-1-oxopropoxy)methyl Ester, Na
      DescriptionA cell-permeable pro-drug of farnesyltransferase (FPT) inhibitor II (Cat. No. 344152). Less active as a farnesyltransferase inhibitor (IC50 = 2.6 µM). Inhibits Ras processing in cells (~100 µM), preventing Ras-mediated transformation.
      FormPale yellow solid
      Chemical formulaC₂₃H₃₉NO₇P . Na
      Structure formulaStructure formula
      Purity≥90% by HPLC
      SolubilityH₂O (50 mg/ml)
      Storage -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
      Toxicity Standard Handling
      ReferencesWang, D., et al. 1998. J. Biol. Chem. 273, 33027.
      Manne, V., et al. 1995. Drug Development Res. 34, 121.

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      Catalogue Number Description  
      344152 FPT Inhibitor II - Calbiochem Show Pricing & Availability

      Categories

      Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Other Inhibitors of Biological Interest > Farnesyltransferase (FTase), Geranylgeranyltransferase (GGTase), & Methyltransferase Inhibitors