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324673 EGFR/ErbB-2 Inhibitor - CAS 179248-61-4 - Calbiochem

The EGFR/ErbB-2 Inhibitor, also referenced under CAS 179248-61-4, controls the biological activity of EGFR/ErbB-2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 4557W, 4-(4-Benzyloxyanilino)-6,7-dimethoxyquinazoline

Primary Target: EGFR
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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      179248-61-4C₂₃H₂₁N₃O₃
      Description
      Overview

      This product has been discontinued.



      A cell-permeable 4-

      anilino quinazoline compound that acts a potent, reversible, and ATP-competitive inhibitors of EGFR and c-erbB2 (IC50 = 20 nM and 79 nM, respectively), members of the type I growth factor receptor family that is involved in breast cancer development and progression. Shown to effectively inhibit the proliferation (IC50 = ~ 1.2-2.5 µM) of tumor cells overexpressing EGRF or c-erbB-2.
      Catalogue Number324673
      Brand Family Calbiochem®
      Synonyms4557W, 4-(4-Benzyloxyanilino)-6,7-dimethoxyquinazoline
      References
      ReferencesCockerill, S., et al. 2001. Bioorg. Med. Chem. Lett. 11, 1401.
      Product Information
      CAS number179248-61-4
      ATP CompetitiveY
      FormOff-white solid
      Hill FormulaC₂₃H₂₁N₃O₃
      Chemical formulaC₂₃H₂₁N₃O₃
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetEGFR
      Primary Target IC<sub>50</sub>20 nM and 79 nM, against EGFR and c-erbB2, respectively
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Carcinogenic / Teratogenic
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      324673 0

      Documentation

      EGFR/ErbB-2 Inhibitor - CAS 179248-61-4 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      EGFR/ErbB-2 Inhibitor - CAS 179248-61-4 - Calbiochem Certificates of Analysis

      TitleLot Number
      324673

      References

      Reference overview
      Cockerill, S., et al. 2001. Bioorg. Med. Chem. Lett. 11, 1401.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision14-September-2007 JSW
      Synonyms4557W, 4-(4-Benzyloxyanilino)-6,7-dimethoxyquinazoline
      DescriptionA cell-permeable, potent, reversible, and ATP-competitive inhibitor of the tyrosine kinase activity of EGFR (IC50 = 20 nM) and c-erbB2 (IC50 = 79 nM), members of the type I growth factor receptor family implicated in the development and progression of various forms of cancer, including breast and small lung cell carcinoma. Shown to effectively inhibit the proliferation (IC50 ~1.2-2.5 µM) of tumor cells overexpressing EGRF or c-erbB-2.
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number179248-61-4
      Chemical formulaC₂₃H₂₁N₃O₃
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (25 mg/ml) or Methanol (1 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Carcinogenic / Teratogenic
      ReferencesCockerill, S., et al. 2001. Bioorg. Med. Chem. Lett. 11, 1401.