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265005 Dexamethasone - CAS 50-02-2 - Calbiochem

Dexamethasone, CAS 50-02-2, is one of the most active and highly stable glucocorticoids. Inhibits the expression of inducible, but not constitutive NOS in vascular endothelial cells (IC50 = 5 nM).

Dexamethasone - CAS 50-02-2 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 9α-Fluoro-16α-methylprednisolone

Primary Target: Phosphorylation of rb protein
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265005
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
50-02-2C₂₂H₂₉FO₅

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265005-100MG
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      		 Plastic ampoule 100 mg
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      Description
      OverviewMost active and highly stable glucocorticoid. Causes a reduction in cyclin A and Cdk2 activity, and inhibition of G1/S transition in osteoblasts. Inhibits the phosphorylation of retinoblastoma (Rb) protein. Inhibits the expression of inducible but not constitutive nitric oxide synthase in vascular endothelial cells (IC50 = 5 nM). Enhances active cation transport in aortic smooth muscle cells by stimulating the Na+ - K+ pump. Induces apoptosis in human thymocytes.
      Catalogue Number265005
      Brand Family Calbiochem®
      Synonyms9α-Fluoro-16α-methylprednisolone
      References
      ReferencesReil, T.D., et al. 2000. J. Surg. Res. 92, 108.
      Smith, E., et al. 2000. J. Biol. Chem. 275, 1992.
      Petit, P.X., et al. 1995. J. Cell Biol. 130, 157.
      Stern, N., et al. 1994. Am. J. Hypertens. 7, 146.
      Donis, J.A., et al. 1993. Biotechniques 15, 786.
      Ohoka, Y., et al. 1993. Biochem. Biophys. Res. Commun. 197, 916.
      Sarin, A., et al. 1993. J. Exp. Med. 178, 1693.
      Vandewalle, A., et al. 1993. J. Cell Physiol. 156, 383.
      Nieto, M.A., et al. 1992. Clin. Exp. Immunol. 88, 341.
      Walsh, D., and Avashia, J. 1992. Cleveland Clin. J. Med. 59, 505.
      Warters, R.L. 1992. Cancer Res. 52, 883.
      Sperber, K., et al. 1991. J. Allergy Clin. Immunol. 87, 490.
      Radomski, M.W., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 10043.
      Bettger, W.J., et al. 1981. Proc. Natl. Acad. Sci. USA 78, 5588.
      Product Information
      CAS number50-02-2
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₂₂H₂₉FO₅
      Chemical formulaC₂₂H₂₉FO₅
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationDexamethasone, CAS 50-02-2, is one of the most active and highly stable glucocorticoids. Inhibits the expression of inducible, but not constitutive NOS in vascular endothelial cells (IC50 = 5 nM).
      Biological Information
      Primary TargetPhosphorylation of rb protein
      Primary Target IC<sub>50</sub>5 nM Inhibiting the expression of inducible but not constitutive nitric oxide synthase in vascular endothelial cells
      Purity≥99% by TLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSTU3980000
      Safety Information
      R PhraseR: 36/37/38-43-63

      Irritating to eyes, respiratory system and skin.
      May cause sensitization by skin contact.
      Possible risk of harm to the unborn child.
      S PhraseS: 24-26-36/37

      Avoid contact with skin.
      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing and gloves.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Carcinogenic / Teratogenic
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      265005-100MG 04055977198508

      Documentation

      Dexamethasone - CAS 50-02-2 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Dexamethasone - CAS 50-02-2 - Calbiochem Certificates of Analysis

      TitleLot Number
      265005

      References

      Reference overview
      Reil, T.D., et al. 2000. J. Surg. Res. 92, 108.
      Smith, E., et al. 2000. J. Biol. Chem. 275, 1992.
      Petit, P.X., et al. 1995. J. Cell Biol. 130, 157.
      Stern, N., et al. 1994. Am. J. Hypertens. 7, 146.
      Donis, J.A., et al. 1993. Biotechniques 15, 786.
      Ohoka, Y., et al. 1993. Biochem. Biophys. Res. Commun. 197, 916.
      Sarin, A., et al. 1993. J. Exp. Med. 178, 1693.
      Vandewalle, A., et al. 1993. J. Cell Physiol. 156, 383.
      Nieto, M.A., et al. 1992. Clin. Exp. Immunol. 88, 341.
      Walsh, D., and Avashia, J. 1992. Cleveland Clin. J. Med. 59, 505.
      Warters, R.L. 1992. Cancer Res. 52, 883.
      Sperber, K., et al. 1991. J. Allergy Clin. Immunol. 87, 490.
      Radomski, M.W., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 10043.
      Bettger, W.J., et al. 1981. Proc. Natl. Acad. Sci. USA 78, 5588.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision21-November-2008 RFH
      Synonyms9α-Fluoro-16α-methylprednisolone
      DescriptionMost active and highly stable glucocorticoid. Inhibits the expression of inducible but not constitutive nitric oxide synthase in vascular endothelial cells (IC50 = 5 nM). Enhances active cation transport in aortic smooth muscle cells by stimulating the Na+-K+ pump. Has anti-inflammatory and antirheumatic properties. Induces apoptosis in human thymocytes. In general, 500-1000 nM of dexamethasone is sufficient to induce apoptosis following a 6 h incubation at 37°C.
      FormWhite solid
      CAS number50-02-2
      RTECSTU3980000
      Chemical formulaC₂₂H₂₉FO₅
      Structure formulaStructure formula
      Purity≥99% by TLC
      SolubilityDMSO (25 mg/ml), chloroform or Ethanol
      Storage +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
      Toxicity Carcinogenic / Teratogenic
      Merck USA index14, 2943
      ReferencesReil, T.D., et al. 2000. J. Surg. Res. 92, 108.
      Smith, E., et al. 2000. J. Biol. Chem. 275, 1992.
      Petit, P.X., et al. 1995. J. Cell Biol. 130, 157.
      Stern, N., et al. 1994. Am. J. Hypertens. 7, 146.
      Donis, J.A., et al. 1993. Biotechniques 15, 786.
      Ohoka, Y., et al. 1993. Biochem. Biophys. Res. Commun. 197, 916.
      Sarin, A., et al. 1993. J. Exp. Med. 178, 1693.
      Vandewalle, A., et al. 1993. J. Cell Physiol. 156, 383.
      Nieto, M.A., et al. 1992. Clin. Exp. Immunol. 88, 341.
      Walsh, D., and Avashia, J. 1992. Cleveland Clin. J. Med. 59, 505.
      Warters, R.L. 1992. Cancer Res. 52, 883.
      Sperber, K., et al. 1991. J. Allergy Clin. Immunol. 87, 490.
      Radomski, M.W., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 10043.
      Bettger, W.J., et al. 1981. Proc. Natl. Acad. Sci. USA 78, 5588.